Korean J Fertil Steril.  1999 Dec;26(3):369-376.

The Effect of Serum Obtained before and after Treatment for Endometriosis on in vitro Fertilization Rate of Mouse Oocyte

• Kim KS
• Min BK
• Rhee HS
• Hong KY
• Lee SY
• Park HJ
• Kim HG

Abstract

OBJECTIVE
To evaluate the effect of serum obtained before and after treatment for endometriosis on in vitro fertilization and development of two cell mouse embryo. Design: Pretreatment and posttreatment comparoson of fertilization of mouse oocyte and embryo development in serum supplement form patients with endometriosis; result were compared using Stuent T-test analysis. METHOD: Infertility Clinic, Department of Obstetrics and Gynecology, Collage of Medicine, Won Kwang university, Korea. Patients was chosed eleven consecutive women with endometriosis. Interventions was all patient underwent laparoscopic or conservative surgery. This was followed by a 6-month course of burserelin acetate 900 microgram/d. Main outcome was measured total number of fertilization and embryo that was fertilization after 24 hours and reached blastocyst stage after 72 hours of incubation were compared before and after treatment. RESULT: Before treatment, 47% of the oocyte were fertilized and 31% of the embryo reached blastocyst stage. After treatment, Significantly more fertilized and Significantly more embryo developed to blastocyst on the stage I and II of endometriosis.
CONCLUSION
The fertilization and embryo toxicity of serum samples from patients with endometriosis is lost after treatment.

MeSH Terms

Animals
Blastocyst
Embryonic Development
Embryonic Structures
Endometriosis*
Female
Fertilization
Fertilization in Vitro*
Gynecology
Humans
Infertility
Korea
Mice*
Obstetrics
Oocytes*
Pregnancy