Analysis of the Factors That Influence the Prognosis of Gallbladder Cancer; Expression of Tumor Suppresser Gene p53 and CD34

Lee, Jung Hun; Yu, Hee Chul; Moon, Woo Sung; Cho, Baik Hwan

Abstract

BACKGROUND/AIMS: A mutation occurs in p53, tumor suppressor gene, the cancer cells may lead to growing due to the inhibition in inducing apoptosis of cancer cells. It is known that CD34, the tumor precursor of hematopoietic cell, is associated with the major histocompatibility class II and affect the neovascularization and it is related with the growth and development of cancer. To investigated the correlation between prognosis of gallbladder cancer and p53 expression of the degree of mutation, CD34 expression and neovascularization.
METHODS
Between March, 1991 and March, 2001, 53 cases of gallbladder cancer which had been confirmed histopathologically, were enrolled in this study and their clinico-athologic findings were anaylzed. We performed p53 and CD34 immunohistological staining and the analysis of Kaplan- Meier survival curve and log rank test.
RESULTS
Among factors considered to determine the prognosis of gallbladder cancer, the presence of p53 overexpression and the degree of its mutation were not significantly correlated with patients survival rate. Also, there were no evidence that the CD34 expression and the degree of mutaion were significantly correlated with patients survival rate. The survival rate of patients with a gallbladder cancer is thought to be affected by the histologic classification, differentation and stage.
CONCLUSION
In this study, p53 mutation and CD34 expression seem to be relatively correlated with progression of gallbladder cancer, but they are no evidence of correlation with survival rate. Therefore, we think p53 or CD34 can not be independent prognostic factor of gallbladder cancer.