Korean J Hepatobiliary Pancreat Surg.  2002 Dec;6(2):138-144.

A 12-year Experience from 1990 to 2001 in Performing Curative Hepatic Resection for Hepatocellular Carcinoma

• Yoo MW
• Choi SH
• Chang SH
• Yi NJ
• Suh KS
• Lee KU

Abstract

BACKGROUND/AIMS: Hepatic resection is an accepted therapeutic modality for hepatocellular carcinoma (HCC). In the present study, surgical results are analyzed with an aim toward further improving the treatment of HCC.
METHODS
We reviewed 831 patients with HCC who underwent a curative hepatic resection in Seoul National University Hospital from 1990 to 2001. We analyzed age, sex, GOT/ GPT, alpha-fetoprotein (alpha FP), HBsAg, anti-HCV, Child classification, size and number of tumor, extent of resection, resection margin, and perioperative transfusion.
RESULTS
1-, 3-, and 5-year overall survival rates were 91.1%, 79.8%, and 71.7%. 1-, 3-, and 5-year disease-free survival rates were 66.9%, 39.3%, and 29.8%. Risk factors of multivariate analysis of recurrence were GOT (>40 IU/L), alpha FP (>20 ng/dl), Child classification (B and C), tumor number (> or =2), tumor size (>5 cm), and extent of resection (major hepatectomy). Prognostic factors of multivariate analysis of overall survival rate were GOT, tumor number, and extent of resection.
CONCLUSION
Although the recurrence rate is still high, identifying an individual patient who is at risk of tumor recurrence (GOT>40 IU/L, alpha FP>20 ng/dl, Child B and C, tumor number> or =2, tumor size >5 cm, and major hepatectomy) is helpful to estimate disease-free survival.

Keyword

Hepatocelluar carcinoma (HCC); Curative hepatic resection

MeSH Terms

alpha-Fetoproteins
Carcinoma, Hepatocellular*
Child
Classification
Disease-Free Survival
Hepatitis B Surface Antigens
Humans
Multivariate Analysis
Recurrence
Risk Factors
Seoul
Survival Rate
Hepatitis B Surface Antigens
alpha-Fetoproteins