Korean J Lab Med.  2003 Aug;23(4):279-281.

An Experience of Cord Blood Transfusion in Cold Hemagglutinin Disease Associated with Mycoplasma pneumoniae Infection

• Lee WH
• Kim CK
• Kim HO
• Kwon HS
• Lyu CJ

Abstract

We report a case of cold hemagglutinin disease associated with Mycoplasma pneumoniae infection treated with cord blood transfusion. Cold hemagglutinin disease is a hemolytic anemia most commonly associated with cold-reactive autoantibody with anti-I specificity. On the basis of the fact that the level of I antigen on cord red blood cells is extremely low, a six year old male patient was transfused with 60 mL of ABO blood type-matched, cord blood. No complication from the transfusion was observed. Due to the deficiency in cord blood supply, filtered irradiated RBC 100 mL was transfused three times thereafter. The hemoglobin level began to increase from the fifth hospital day. The patient was discharged without additional transfusion on the eleventh hospital day. No remarkable complications were noted at the time of discharge.

Keyword

Cold hemagglutinin disease; Cord blood transfusion; Cold-reactive autoantibody

MeSH Terms

Anemia, Hemolytic
Erythrocytes
Fetal Blood*
Hemagglutinins*
Humans
Male
Mycoplasma pneumoniae*
Pneumonia, Mycoplasma*
Sensitivity and Specificity
Hemagglutinins