Korean J Vet Res.  2013 Sep;53(3):181-184.

Clinical trial of diltiazem on dystrophic calcinosis cutis in a dog

Affiliations
  • 1College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea. parksj@cnu.ac.kr

Abstract

Dystrophic calcinosis cutis associated with spontaneous hyperadrenocorticism was diagnosed in a 8-year-old female Chihuahua dog with erythematous, erosive, numerous papules, plaques, and crusts on the bilateral trunk, and inguinal region. Serum biochemical abnormalities included increases in alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and cholesterol. Radiographs showed mild hepatomegaly and subcutaneous lobulated calcific deposits. Histopathologic examination demonstrated diffuse deposition of basophilic calcified material in the dermis. Von Kossa's stain confirmed calcium deposition. Therapy with diltiazem was useful in resolving calcinosis.

Keyword

diltiazem; dog; dystrophic calcinosis cutis; hyperadrenocorticism

MeSH Terms

Adrenocortical Hyperfunction
Alanine Transaminase
Alkaline Phosphatase
Animals
Basophils
Calcinosis*
Calcium
Child
Cholesterol
Dermis
Diltiazem*
Dogs*
Female
gamma-Glutamyltransferase
Hepatomegaly
Humans
Alanine Transaminase
Alkaline Phosphatase
Calcium
Cholesterol
Diltiazem
gamma-Glutamyltransferase
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