Ann Dermatol.  2006 Oct;18(2):91-96. 10.5021/ad.2006.18.2.91.

A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma

• Kim JK
• Kim TH
• Park TH
• Yoo JH
• Kim KJ

• KMID: 1882000
• DOI: http://doi.org/10.5021/ad.2006.18.2.91

Abstract

We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.

Keyword

Bcl-2; Post-GC B-cell; Secondary cutaneous diffuse large B-cell lymphoma

MeSH Terms

Aged
Antibodies, Monoclonal
B-Lymphocytes*
Cheek
Cisplatin
Classification
Dermis
Drug Therapy
Humans
Lymph Nodes
Lymphocytes
Lymphoma
Lymphoma, B-Cell*
Neck
Pneumonia
Skin
World Health Organization
Antibodies, Monoclonal
Cisplatin