Korean J Thorac Cardiovasc Surg.  2004 Mar;37(3):245-251.

Changes of Coagulability after Off-pump CABG: Comparison with On-pump CABG

• Chang WI
• Kim KB
• Kim WS
• Chung CH
• Huh JH
• Chang JM
• Lee DS
• Han KS

Abstract

BACKGROUND: Hemostatic function is regarded to be preserved after an off-pump coronary artery bypass grafting (CABG), compared to conventional CABG, and the preserved hemostatic function may increase thrombotic occlusion of the graft. We studied the changes of hemostatic variables in patients undergoing off-pump CABG, and compared to those of on-pump CABG. MATERIAL AND METHOD: We studied the changes of coagulation function in 11 patients who underwent off-pump CABG (group I), and compared them with those of 11 patients who underwent on-pump CABG and Dor procedure (group II). Coagulation status was evaluated by thromboelastography and blood coagulation test preoperatively, postoperative 1st day, 2nd day, 3rd day, and 5th day, respectively. RESULT: Among the variables measured by thromboelastography (such as r time, k time, alpha angle, and MA value) and blood coagulation test (such as factor VII, protein S, protein C, antithrombin III, activated protein C resistance test, plasminogen, D-dimer, prothrombin time, activated partial thromboplastin time, platelet count, hemoglobin, and fibrinogen), there were significant differences in the MA value, alpha angle, and platelet counts between the two groups. MA values were 140+/-72% and 153+/-98% in group I, and 87+/-27% and 78+/-28% in group II, at postoperative 3rd and 5th days, respectively (p<0.05). alpha angle was 122+/-92% in group I and 69+/-23% in group II at postoperative 3rd day (p=0.09). Platelet count was 63+/-55% in group I and 33+/-13% in group II at postoperative 3rd day (p<0.05).
CONCLUSION
Patients who underwent off-pump CABG showed increased coagulability during postoperative periods, compared to those who underwent on-pump CABG. Our data suggest that aggressive perioperative anticoagulation therapy is warranted in patients undergoing off-pump CABG.

Keyword

Coagulation; Off-pump; Thromboelastography; Coronary artery bypass

MeSH Terms

Activated Protein C Resistance
Antithrombin III
Blood Coagulation Tests
Coronary Artery Bypass
Coronary Artery Bypass, Off-Pump
Factor VII
Humans
Partial Thromboplastin Time
Plasminogen
Platelet Count
Postoperative Period
Protein C
Protein S
Prothrombin Time
Thrombelastography
Transplants
Antithrombin III
Factor VII
Plasminogen
Protein C
Protein S