Korean J Thorac Cardiovasc Surg.  2001 Sep;34(9):711-715.

Treatment of Deep Venous Thromboses of Lower Leg with Thrombolysis

• Lee JW

Abstract

BACKGROUND: Deep venous thrombosis(DVT) is a curable disease when it is appropriately treated in the early stages of onset. The long term follow up of chronic DVT shows poor prognosis with serious complications such as venous valvular insufficiency, venous claudication, venous ulcer and leg swelling. Thrombolytic therapy is a very active treatment that delivers thrombolytic agents via catheter to the target thrombi. The aim of this study is to evaluate the effect of catheter directed thrombolysis using urokinase to acute DVT. MATERIAL AND METHOD: We studied 5 patients, who were diagnosed as acute DVT and had no contraindication for selective hemolysis using urokinase. RESULT: All the patients were successfully recanalized. Total infusion time of urokinase was 2.0+/-0.6 days, and the amount was 5.9+/-2.45 million IU. In 4 patients, who were diagnosed as May-Therner syndrome, we performed the balloon angioplasty and inserted the stent at the stenotic portion. There were minor complications such as hematuria, hematoma at puncture site, and all of them are self limited.
CONCLUSION
Catheter induced thrombolysis is an effective treatment in acute DVT.

Keyword

Deep Vein Thrombosis; Thrombolytic therapy; Stent

MeSH Terms

Angioplasty, Balloon
Catheters
Fibrinolytic Agents
Follow-Up Studies
Hematoma
Hematuria
Hemolysis
Humans
Leg*
Prognosis
Punctures
Stents
Thrombolytic Therapy
Urokinase-Type Plasminogen Activator
Varicose Ulcer
Venous Insufficiency
Venous Thrombosis*
Fibrinolytic Agents
Urokinase-Type Plasminogen Activator