Neonatal Med.  2013 Nov;20(4):413-421. 10.5385/nm.2013.20.4.413.

Association of Interleukin-1alpha-889, beta-31, beta-511 Polymorphism with Risk of Bronchopulmonary Dysplasia

• Kang JH
• Lee JJ
• Cho SI
• Choi Y
• Jo HS
• Lee KH

• KMID: 1876426
• DOI: http://doi.org/10.5385/nm.2013.20.4.413

Abstract

PURPOSE
Although improvements in neonatal care techniques have increased the survival rate of preterm infants, bronchopulmonary dysplasia (BPD) remains an important factor in neonatal mortality and morbidity. BPD is a multifactorial disease associated with genetic and clinical risk factors related to lung development and perinatal inflammation. Interleukin-1 (IL-1) is a crucial cytokine in the early stages of inflammation. In the present study, we aimed to determine the association between the IL-1 polymorphisms, clinical risk factors, and BPD in preterm infants.
METHODS
The study was performed who consented infants born at less than 34 weeks' gestation. The alleles of the 3 sites of the IL-1 gene (IL-1alpha-889, IL-1beta-31, and IL-1beta-511) were determined using Taqman(R)-based allelic discrimination assays. Clinical data were reviewed from the medical records.
RESULTS
A total of 31 infants with BPD and 73 control infants were enrolled in the study. The gestational age (P=0.001) and birth weight (P=0.001) were lower in the BPD group compared to those in the control group. The incidence of respiratory distress syndrome (RDS; P=0.002), patent ductus arteriosus (P=0.01), and retinopathy of prematurity (P<0.001) was higher in the BPD group compared to that in the control group. The frequency of IL-1alpha-889TT was higher in the BPD group (6.5% vs. 0.0%, P=0.028) compared to that in the control group. The frequencies of IL-1alpha-889T, IL-1beta-31T, and IL-1beta-511T did not differ between the BPD and control groups. In logistic regression analysis, gestational age and RDS were found to be associated with BPD.
CONCLUSION
IL-1alpha-889, IL-1beta-31, and IL-1beta-511 polymorphisms are not associated with the development of BPD in preterm infants.

Keyword

Bronchopulmonary dysplasia; Polymorphism; Interleukin-1

MeSH Terms

Alleles
Birth Weight
Bronchopulmonary Dysplasia*
Discrimination (Psychology)
Ductus Arteriosus, Patent
Gestational Age
Humans
Incidence
Infant
Infant Mortality
Infant, Newborn
Infant, Premature
Inflammation
Interleukin-1
Logistic Models
Lung
Medical Records
Pregnancy
Retinopathy of Prematurity
Risk Factors
Survival Rate
Interleukin-1