Korean J Med.
2002 May;62(5):570-574.
A case of combined deficiency of antithrombin III and protein C complicated by recurrent venous thrombosis
- Affiliations
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- 1Department of Internal Medicine, Seoul Adventist Hospital, Seoul, Korea. js36park@hanmail.net
- 2Department of General Surgery, Seoul Adventist Hospital, Seoul, Korea.
- 3Department of Clinical Pathology, Seoul Adventist Hospital, Seoul, Korea.
- 4Department of Anatomic Pathology, Seoul Adventist Hospital, Seoul, Korea.
Abstract
- Primary venous thrombosis caused by deficiency or qualitative abnormality of antithrombin III, protein C and protein S is usually inherited as an autosomal dominant trait. Usually, deep vein thrombosis or pulmonary thromboembolism is developed by such abnormalities, however, mesenteric vein thrombosis is rarely reported. A 27-year-old man with previous history of deep vein thrombosis underwent segmental resection of jejunum due to mesenteric vein thrombosis complicated by necrosis of jejunum. Postoperative investigation disclosed combined deficiency of antithrombin III and protein C. His son also showed deficiency of antithrombin III. Postoperatively, he is on life-long warfarin therapy without experiencing recurrence of venous thrombosis.
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