Effectiveness of Flumazenil against Midazolam as Premedication for Upper Gastrointestinal Endoscopy

Yun, Uk Don; Choi, Seok Ryeol; Lee, Jong Hun; Choi, Dae Hyun; Shin, Jong Min; Rho, Myung Hwan; Han, Sang Young; Shin, Woo Won

Abstract

BACKGROUND/AIMS
Midazolam is utilized as a premedication for uppoer gastrointestinal endoscopy. Midazolam has a more rapid onset of reaction than that of diazepam and its duration is shorter. But the Consciousness of premedicated patients has not been regained sooner. The Purpose of this study was to examine the effectiveness of flumazenil against midazolam as premedication for upper gastrointesinal endoscopy.
METHODS
Sixty patients underwent upper gastrointestinal endoscopy. These patients were divided to three groups: Group I included twenty patients without premedication; Group II Included twenty patients with premedication of midazolam and then were not given an antisedative agent excluign of normal saline; and Group III included the others with midazolam and flumazenil as an antisedative agent.
RESULTS
There was no change in vital signs after midazolam and flumazenil as an antisedative agent.
RESULTS
There was no change in vital signs after midazolam injection, compared with presedation value. Modified Steward Coma Scale showed a significant increase after flumazenil injection as an antagonist of midazolam. The assessment of the endoscopist and the comfort of patients were satisfactory. When the 40 patients were asked about their willingness to undergo the same procedure in the future, thirty-four patients responded favorably.
CONCLUSION
Midazolam was safe and effective for sedation for upper gastrointestinal endoscopy. There was rapid regaining of consciousness with flumazenil indection after midazolam, so the use of flumazenil against midazolam injection also appeared to be effective.