Korean J Clin Pathol.  1998 Mar;18(1):26-28.

Relationship between Myelodysplastic Syndrome and Epstein-Barr Virus or Human Parvovirus B19 Infection

• Lee KA
• Choi JR
• Song KS

Abstract

BACKGROUND: The mechanisms responsible for the disturbed hematopoiesis in myelodysplastic syndrome (MDS) include the expansion of abnormal clones, defects in cellular differentiation and the perturbation in the production of hematopoietic regulatory factors. Recently, viral infection such as immunodeficiency virus is known to induce myelodysplasia. And viral infection evokes the production of several cytokines. Therefore, abnormal production of cytokine may be a potential candidate for the pathogenesis of MDS after viral infections such as Epstein-Barr virus (EBV) and human parvovirus B19.
METHODS
We investigated bone marrow aspiration slides from 17 patients with MDS referred for the bone marrow study, over a period from January, 1992 to April, 1996. To clarify the contribution of EBV and human parvovirus B19 infections to the pathogenesis of MDS, DNA-PCR for EBV and human parvovirus B19 was used.
RESULTS
The EBV and human parvovirus B19-PCR results were all negative in 17 patients with MDS.
CONCLUSIONS
EBV and human parvovirus B19 infections may not be associated with the major pathogenesis of MDS.

Keyword

Myelodysplastic syndrome; Epstein-Barr virus; Human parvovirus B19

MeSH Terms

Bone Marrow
Clone Cells
Cytokines
Hematopoiesis
Herpesvirus 4, Human*
Humans*
Myelodysplastic Syndromes*
Parvovirus
Parvovirus B19, Human*
Cytokines