Korean J Anesthesiol.  2006 Jun;50(6):637-641. 10.4097/kjae.2006.50.6.637.

The Effects of Remifentanil Pretreatment on Rocuronium Injection Pain and Cardiovascular Response during Anesthetic Induction

• Lim CS
• Shin YS

• KMID: 1862238
• DOI: http://doi.org/10.4097/kjae.2006.50.6.637

Abstract

BACKGROUND: Remifentanil is an opioid agonist with rapid onset and ultra-short duration of action. Rocuronium bromide can elicit a high incidence of pain when intravenous injection. In this study, the quantitative effect of remifentanil pretreatment on the injection pain of rocuronium and cardiovascular response during anesthetic induction were evaluated.
METHODS
Eighty adult female patients undergoing gynecological procedures with general anesthesia were analyzed for this study. Patients were randomly allocated to one of four groups. Patients received 2 ml of normal saline (n = 20), 2 ml (40 mg) of 2% lidocaine (n = 20), 2 ml of remifentanil 0.5 microgram/kg (n = 20) or 2 ml of remifentanil 1 microgram/kg (n = 20) 60 seconds prior to administration of rocuronium 0.7 mg/kg. Pain was assessed after rocuronium injection. Systolic and diastolic arterial blood pressure and heart rates were measured before and during anesthetic induction.
RESULTS
Both remifentanil and lidocaine have the good effect in minimizing the rocuronium injection pain. But, only 1 microgram/kg of remifentanil blunts the hypertension after endotracheal intubation.
CONCLUSIONS
A bolus dose (1 microgram/kg) of remifentanil may be used for minimizing the rocuronium injection pain and blunting the hypertension after endotracheal intubation.

Keyword

anesthetic induction; injection pain; remifentanil; rocuronium

MeSH Terms

Adult
Anesthesia, General
Arterial Pressure
Female
Heart Rate
Humans
Hypertension
Incidence
Injections, Intravenous
Intubation, Intratracheal
Lidocaine
Lidocaine