Korean J Anesthesiol.  1996 Feb;30(2):139-146. 10.4097/kjae.1996.30.2.139.

The Effect of Desmopressin Acetate on Coagulation in Rabbits Subjected to Severe Hemorrhagic Shock

• Park CJ
• Lee JY
• Yoo YN

• KMID: 1860384
• DOI: http://doi.org/10.4097/kjae.1996.30.2.139

Abstract

BACKGROUND: Desmopressin acetate (DDAVP) may improve hemostasis in congenital or acquired disorders of coagulation and reduce operative blood loss in patients undergoing surgical procedures. The effects of DDAVP on coagulation in hemorrhagic shock were studied in rabbits subjected to severe hemorrhage.
METHODS
20 rabbits were bled to shock and infused lactated Ringer's solution simultaneously so that the mean arterial pressure were maintained above 50 mmHg. Animals were randomly received DDAVP 0.3 ug/kg (group Dl), 3 ug/kg (group D10) or saline (group S) over 15 minutes. Bleeding time and factor VIII coagulant activity (FVIII:C) were measured before, after shock and 45 minutes after DDAVP or saline infusion.
RESULTS
After shock, bleeding time was not changed but FVIII:C was decreased significantly in all groups. After saline or DDAVP infusion, bleeding time was not changed in group S and group Dl, whereas shortened in group D10 from 107.5+/-11.3 second to 87.5+/-17.5 second (P<0.05). After saline or DDAVP infusion, FVIII:C was decreased in group S and group Dl (P<0.05), but not changed in group D10.
CONCLUSIONS
Infusion of DDAVP 3 ug/kg shortens bleeding time and causes an increase of FVIII:C than other groups in rabbits resuscitated from hemorrhagic shock.

Keyword

Pharmacology; desmopressin acetate; Shock; hemorrhagic

MeSH Terms

Animals
Arterial Pressure
Bleeding Time
Deamino Arginine Vasopressin*
Factor VIII
Hemorrhage
Hemostasis
Humans
Pharmacology
Rabbits*
Shock
Shock, Hemorrhagic*
Deamino Arginine Vasopressin
Factor VIII