Korean Circ J.
2004 Jun;34(6):565-573. 10.4070/kcj.2004.34.6.565.
Association of Cholesteryl Ester Transfer Protein Gene Polymorphism with Serum Lipid Concentration and Coronary Artery Disease in Korean Men
- Affiliations
-
- 1Cardiovascular Research Institute, Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.
- 3Research Institute of Science for Aging, Yonsei University, Seoul, Korea.
- 4Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 1858906
- DOI: http://doi.org/10.4070/kcj.2004.34.6.565
Abstract
- BACKGROUND AND OBJECTIVES
Cholesteryl ester transfer protein (CETP) plays a key role in the reverse cholesterol transport pathway. The purpose of this study was to investigate the association of CETP gene polymorphism with the plasma lipid levels and coronary artery disease (CAD) in Korean men.
SUBJECTS AND METHODS
Two hundred and sixteen healthy control subjects (46.8+/-10.6 y) and 95 patients with CAD (58.2+/-8.8 y) were examined. The genotypes of C-629A, Taq1B and I405V were determined by the SNP-IT assay.
RESULTS
The allele frequencies of the C:A in the C-629A, B1:B2 in the Taq1B and I:V in the I405V in the control group were 0.51:0.49, 0.63:0.37 and 0.55:0.45, respectively. The genotype distributions of the C-629 A and Taq1B polymorphisms in the CAD patients did not differ from those in the control group. No variation in the CETP genotype was associated with disease progression in the CAD group. The HDL cholesterol in -629A homozygous and Taq1B B2 homozygous were higher than those of the other genotypes. The Taq1B B2 carrier was an independent determinant for HDL cholesterol in the control group. However, I405V polymorphism was not associated with HDL cholesterol. The V allele in the I405V polymorphism was associated with reduced CAD events after controlling the age, BMI and other risk factors (OR:0.4, p<0.01).
CONCLUSION
The frequencies of Taq1B and C-629A variants between the healthy and CAD groups did not differ. The B2 carrier in the Taq1B polymorphism was associated with a higher HDL cholesterol concentration. The V variation in the I405V polymorphism had a protective effect against the development of CAD in Korean men.
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