Korean J Psychopharmacol.  2011 Jan;22(1):34-39.

Adjunctive Treatment with Aripiprazole for Risperidone-Induced Amenrrhea

Affiliations
  • 1Department of Psychiatry, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea. jooshim@inje.ac.kr
  • 2Clinical Trial Center, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea.

Abstract


OBJECTIVE
Hyperprolactinemia and associated side effect, amenorrhea, often occur with risperidone treatment. We investigated the effect of adjunctive treatment with aripiprazole on risperidone induced amenorrhea in female patients with schizophrenia.
METHODS
A retrospective chart review of 24 female patients with adjunctive aripiprazole treatment for risperidone induced amenorrhea between August 2008 and July 2009 was conducted. The information collected included age, menstrual cycle, duration of no menstruation, prolactin level (before aripiprazole treatment and after regaining menstruation), dose of risperidone and aripiprzole, time from starting aripiprazole adjunctive treatment to regaing menstruation. The Student's t-test, Pearson's Chi-square test were used for data analysis.
RESULTS
Mean percent decrease in prolactin level for all aripiprazole-treated patients was 71.4+/-8.6%. 85.7% (18/21) of patients resumed menstruation, while 14.3% (3/21) did not regain. In patients with regaining menstruation, mean time from starting aripiprazole to restarting menstruation was 6.6+/-2.4 weeks, mean dose of aripiprazole was 12.2+/-3.9 mg/day (dose range, 5 mg to 20 mg/day). Aripiprazole dose for regaining menstruation was not significantly correlated with baseline prolactin level. CGI score was not significantly changed after aripiprazole treatment. The cutoff point of prolactin level significantly increasing amenorrhea was 40 ng/mL.
CONCLUSION
Adjunctive aripiprazole treatment is very effective to treat risperidone induced amenorrhea in female patients with schizophrenia.

Keyword

Amenorrhea; Hyperprolacinemia; Risperidone; Aripiprazole

MeSH Terms

Amenorrhea
Chi-Square Distribution
Female
Humans
Hyperprolactinemia
Menstrual Cycle
Menstruation
Piperazines
Prolactin
Quinolones
Retrospective Studies
Risperidone
Schizophrenia
Piperazines
Prolactin
Quinolones
Risperidone
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