Tuberc Respir Dis.  2009 May;66(5):370-373. 10.4046/trd.2009.66.5.370.

A Case of Pulmonary Thromboembolism in Crohn's Disease

• Chung ES
• Kim JH
• Jung JH
• Shin JY
• Yeom JO
• Kang JY
• Yoon HK
• Song JS

• KMID: 1846400
• DOI: http://doi.org/10.4046/trd.2009.66.5.370

Abstract

Crohn's disease, a major form of inflammatory bowel disease (IBD), is a chronic inflammatory condition that is characterized by microvascular and macrovascular involvement. Some extraintestinal complications can occur due to chronic systemic inflammation in IBD. Among them, a pulmonary thromboembolism is a rare manifestation of IBD but is associated with a high morbidity and mortality. To our best of knowledge, there is only one case report of a pulmonary thromboembolism as a complication of Crohn's disease in Korea. We present another rare case of pulmonary thromboembolism as complication in a 25-year-old man with underlying Crohn's disease.

Keyword

Crohn's disease; Pulmonary thromboembolism

MeSH Terms

Adult
Crohn Disease
Humans
Inflammation
Inflammatory Bowel Diseases
Korea
Pulmonary Embolism

Figure

• 

  Figure 1 Chest X-ray shows no abnormal findings.

• 

  Figure 2 Chest computed tomography demonstrates filling defects from left main pulmonary artery to the both segmental pulmonary arteries (A, B).

Reference

1. Wells PS, Owen C, Doucette S, Fergusson D, Tran H. Does this patient have deep vein thrombosis? JAMA. 2006. 295:199–207.

2. Calder KK, Herbert M, Henderson SO. The mortality of untreated pulmonary embolism in emergency department patients. Ann Emerg Med. 2005. 45:302–310.

3. Scientific Committee for National Survey of Acute Pulmonary Thromboembolism, Korean Academy of Tuberculosis and Respiratory Diseases. The national survey of acute pulmonary thromboembolism in Korea. Tuberc Respir Dis. 2003. 54:5–14.

4. Papa A, Scaldaferri F, Danese S, Guglielmo S, Roberto I, Bonizzi M, et al. Vascular involvement in inflammatory bowel disease: pathogenesis and clinical aspects. Dig Dis. 2008. 26:149–155.

5. Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T, et al. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut. 2004. 53:542–548.

6. Chung C, Kang DH, Kim EA, Hong SH, Kong HS, Park HC, et al. A case of pulmonary embolism in recurrent ileal Crohn's disease after total colectomy. Korean J Gastrointest Endosc. 2001. 22:111–115.

7. Bargen JA, Barker NW. Extensive arterial and venous thrombosis complicating chronic ulcerative colitis. Arch Intern Med. 1936. 58:17–31.

8. Solem CA, Loftus EV, Tremaine WJ, Sandborn WJ. Venous thromboembolism in inflammatory bowel disease. Am J Gastroenterol. 2004. 99:97–101.

9. Liebman HA, Kashani N, Sutherland D, McGehee W, Kam AL. The factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease. Gastroenterology. 1998. 115:830–834.

10. Jackson LM, O'Gorman PJ, O'Connell J, Cronin CC, Cotter KP, Shanahan F. Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. QJM. 1997. 90:183–188.

11. Collins CE, Rampton DS. Review article: platelets in inflammatory bowel disease--pathogenetic role and therapeutic implications. Aliment Pharmacol Ther. 1997. 11:237–247.

12. Sonoda K, Ikeda S, Mizuta Y, Miyahara Y, Kohno S. Evaluation of venous thromboembolism and coagulation-fibrinolysis markers in Japanese patients with inflammatory bowel disease. J Gastroenterol. 2004. 39:948–954.