Korean J Med.  2013 May;84(5):713-717.

Unusual Complication of Crohn's Disease: Portal Hypertension Related with Rapid Progression of Portal Vein and Superior Mesenteric Vein Thrombosis

• Oh DY
• Jung HK
• Kwon KJ
• Ryu JI
• Song ME
• Yoo K
• Moon IH

Abstract

Thromboembolic events are rare among systemic complications of inflammatory bowel disease; however, they are a significant cause of mortality when they occur. Several reports have considered thromboembolic events in patients with ulcerative colitis presenting with venous or arterial thromboembolism, such as cerebral thrombosis, deep vein thrombosis, pulmonary thromboembolism, portal vein thrombosis, or mesenteric vein thrombosis. However, increased coagulability related to Crohn's disease is extremely rare compared with that of ulcerative colitis. We report a case of a 42-year-old man with complicated portal hypertension that occurred due to extensive portal vein and mesenteric vein thrombosis. He had a monozygotic twin brother who was also in remission with Crohn's disease. The patient showed protein C and protein S deficiencies; however, he recovered with early anticoagulation therapy.

Keyword

Crohn's disease; Venous thromboembolism; Portal hypertension

MeSH Terms

Colitis, Ulcerative
Crohn Disease
Humans
Hypertension, Portal
Intracranial Thrombosis
Mesenteric Veins
Portal Vein
Protein C
Protein S
Pulmonary Embolism
Siblings
Thromboembolism
Thrombosis
Twins, Monozygotic
Venous Thromboembolism
Venous Thrombosis
Protein C
Protein S