J Korean Soc Clin Toxicol.  2015 Jun;13(1):50-54.

A Case of Podostroma Cornu-Damae Intoxication Induced Pancytopenia and Skin Desquamation: Successful Treatment with Granulocyte Colony Stimulation Factor (G-CFS)

• Kim JS
• Kim GW
• Chung JI
• Sim MK
• Yoon KC
• Choi YH
• Yi HR
• Choi IZ
• Shim CS
• Han JH

Abstract

Podostroma cornu-damae is a rare species of fungus belonging to the Hyocreaceae family. Its fruit body is highly toxic, as it contains trichothecene mycotoxins. The morphology is similar to that of immature Ganoderma lucidum, making identification difficult for non-experts. We experienced such a case of a 56- year-old male who picked and consumed podostroma cornu-damae, and consumed. Later that day, he developed digestive system symptoms, including nausea, vomiting, and abdominal pain. He presented to the emergency room (ER), there were no abnormal physical findings, symptoms improved after gastric lavage, and the patient voluntarily discharged himself on the same day. The following day, as the symptoms gradually deteriorated, he was admitted via the ER. He was presented with severe pancytopenia, alopecia, desquamation of skin, and acute renal failure. He recovered without any complications after conservative care, antibiotics therapy, and granulocyte colony stimulating factor administration. The most commonly reported complications of podostroma cornu-damae intoxication were reported pancytopenia, infection, disseminated intravascular coagulation, acute renal failure, etc. since Prevention is especially important because its toxicity can be lethal and there is no particular treatment to date, prevention is especially important. Promotion and education for the public are needed.

Keyword

Mushrooms; Podostroma cornu-damae; Trichothecene; Mycotoxins; Pancytopenia; Radiomimetic injury

MeSH Terms

Abdominal Pain
Acute Kidney Injury
Agaricales
Alopecia
Anti-Bacterial Agents
Colony-Stimulating Factors
Digestive System
Disseminated Intravascular Coagulation
Education
Emergency Service, Hospital
Fruit
Fungi
Gastric Lavage
Granulocytes*
Humans
Male
Mycotoxins
Nausea
Pancytopenia*
Reishi
Skin*
Vomiting
Anti-Bacterial Agents
Colony-Stimulating Factors
Mycotoxins