Radiat Oncol J.  2014 Dec;32(4):262-265. 10.3857/roj.2014.32.4.262.

Radiation recall dermatitis induced by tamoxifen during adjuvant breast cancer treatment

Affiliations
  • 1Department of Internal Medicine, Jeju National University Hospital, Jeju, Korea. mwkkim@naver.com
  • 2Department of Radiation Oncology, Jeju National University Hospital, Jeju, Korea.
  • 3Department of General Surgery, Jeju National University Hospital, Jeju, Korea.

Abstract

Tamoxifen and radiotherapy are used in breast cancer treatment worldwide. Radiation recall dermatitis (RRD), induced by tamoxifen, has been rarely reported. Herein, we report a RRD case induced by tamoxifen. A 47-year-old woman had a right quadrantectomy and an axillary lymph node dissection due to breast cancer. The tumor was staged pT2N0; it was hormone receptor positive, and human epidermal growth factor receptor 2 negative. The patient received adjuvant chemotherapy followed by tamoxifen and radiotherapy. After 22 months of tamoxifen, the patient developed a localized heating sensation, tenderness, edema, and redness at the irradiated area of the right breast. The symptoms improved within 1 week without treatment. Three weeks later, however, the patient developed similar symptoms in the same area of the breast. She continued tamoxifen before and during dermatitis, and symptoms resolved within 1 week.

Keyword

Tamoxifen; Radiation recall dermatitis; Treatment

MeSH Terms

Breast
Breast Neoplasms*
Chemotherapy, Adjuvant
Dermatitis
Edema
Female
Heating
Hot Temperature
Humans
Lymph Node Excision
Middle Aged
Radiodermatitis*
Radiotherapy
Receptor, Epidermal Growth Factor
Sensation
Tamoxifen*
Receptor, Epidermal Growth Factor
Tamoxifen
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