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Knockdown of vps54 aggravates tamoxifen-induced cytotoxicity in fission yeast

Lee S, Nam M, Lee AR, Baek ST, Kim MJ, Kim JS, Kong AH, Lee M, Lee SJ, Kim SY, Kim DU, Hoe KL

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)‒positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To...
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Bilateral symmetrical lipoma of the buccal fat pad as an incidental finding in a woman with weight gain after tamoxifen: a case report

Koh IS, Kim JW, Yun JY, Chung EH, Yang YI, Sun H

Although lipoma is a common benign tumor, it occurs relatively infrequently in the oral and maxillofacial areas, and only 31 cases of lipoma in the buccal fat pad have been...
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Fatty Liver in Hormone ReceptorPositive Breast Cancer and Its Impact on Patient's Survival

Taroeno-Hariadi KW, Putra YR, Choridah L, Widodo I, Hardianti MS, Aryandono T

Purpose: Long-term estrogen inhibition may cause fatty liver disease (non-alcoholic fatty liver disease; NAFLD) among other adverse conditions such as osteoporosis, climacteric symptoms, thromboembolism, dyslipidemia, and metabolic syndrome. The prevalence...
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Hair Changes and Hair Care in Women Treated with Adjuvant Hormone Therapy for Breast Cancer: A Pilot Study

Lee JK, Kim CH, Hong D, Jung KE, Seo YJ, Kim CD, Lee JS, Kwon IS, Park S, Lee Y

  • KMID: 2519508
  • Korean J Dermatol.
  • 2021 Aug;59(7):521-526.
Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective:...
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Implications of Tamoxifen Resistance in Palbociclib Efficacy for Patients with Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: Subgroup Analyses of KCSG-BR15-10 (YoungPEARL)

Lee J, Im SA, Kim GM, Jung KH, Kang SY, Park IH, Kim JH, Ahn HK, Park YH

Purpose YoungPEARL (KCSG-BR15-10) trial demonstrated a significant progression-free survival (PFS) benefit for premenopausal patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–) metastatic breast cancer (MBC) for palbociclib plus...
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Cell Type-specific Knockout with Gli1-mediated Cre Recombination in the Developing Cerebellum

Choi JM, Acharya R, Marasini S, Narayan B, Lee KW, Hwang WS, Chang DY, Kim SS, Kim HS

  • KMID: 2517473
  • Exp Neurobiol.
  • 2021 Jun;30(3):203-212.
  • doi: 10.5607/en21017
The inducible Cre-loxP system provides a useful tool for inducing the selective deletion of genes that are essential for proper development and enables the study of gene functions in properly...
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Liver Infarction and Venous Thromboembolism after Tamoxifen Use in an ADPKD Patient with Encapsulating Peritoneal Sclerosis: A Case Report

Kwak KM, Choi GH, Shim KE, Jin HY, Kim SH, Yoon JW, Kim H

Encapsulating peritoneal sclerosis (EPS) is a potentially fatal complication after long-term peritoneal dialysis, and tamoxifen can be used for its prevention and treatment. However, tamoxifen is known to increase the...
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Effect of Adjuvant Hormonal Therapy on the Development of Pulmonary Fibrosis after Postoperative Radiotherapy for Breast Cancer

Anzic M, Marinko T

Breast cancer is the most common malignancy among women. Therefore, it is of paramount importance to study the adverse effects of oncological treatment of breast cancer, with one of adverse...
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Tamoxifen-inducible cardiac-specific Cre transgenic mouse using VIPR2 intron

Chin HJ, Lee Sy, Lee D

Genetically engineered mouse models through gene deletion are useful tools for analyzing gene function. To delete a gene in a certain tissue temporally, tissue-specific and tamoxifen-inducible Cre transgenic mice are...
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Medical Treatment for Idiopathic Gynecomastia with Tamoxifen

Jung CY, Min JW

Purpose: Gynecomastia is a common condition caused by various factors and characterized by the overdevelopment of the male breast glandular tissue. It can cause pain and discomfort, which may require...
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Risk Factors Associated with Endometrial Pathology in Premenopausal Breast Cancer Patients Treated with Tamoxifen

Lee M, Piao J, Jeon MJ

PURPOSE: To evaluate factors associated with endometrial pathology during tamoxifen use in premenopausal breast cancer (BC) patients. MATERIALS AND METHODS: We reviewed the medical records of premenopausal BC patients treated with...
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Predicting the Benefit of Adjuvant Aromatase Inhibitor Therapy in Postmenopausal Breast Cancer Patients with Phosphorylated S6K1 Expression Status

Choi J, Park CS, Seong MK, Seol H, Kim JS, Park IC, Noh WC, Kim HA

PURPOSE: Phosphorylated ribosomal S6 kinase 1 (pS6K1) is a major downstream regulator of the mammalian target of rapamycin (mTOR) pathway. Recent studies have addressed the role of S6K1 in adipogenesis....
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The effect of Tamoxifen on Patients with Gynecomastia

Oh JM, Won TW

PURPOSE: Gynecomastia is the most common cause of male breast enlargement and is a disease which can occur in men of all ages. The purpose of this study was to...
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Inhibition of tamoxifen's therapeutic effects by emodin in estrogen receptor-positive breast cancer cell lines

Kim YG, Park YH, Yang EY, Park WS, Park KS

PURPOSE: This study was aimed to investigate the combination effect of endoxifen and emodin on estrogen receptor (ER) positive breast cancer cell lines and to explain the mechanism of the...
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Prediction of Late Breast Cancer-Specific Mortality in Recurrence-Free Breast Cancer Survivors Treated for Five Years with Tamoxifen

Baek SY, Kwon JY, Lee YJ, Gwark SC, Lee SB, Kim J, Chung IY, Ko BS, Kim HJ, Kim SB, Ahn SD, Gong G, Son BH, Ahn SH, Lee JW

PURPOSE: The extension of endocrine therapy beyond 5 years for recurrence-free survivors of breast cancer improves survival; however, the issue on how to clinically identify appropriate candidates remains controversial. This...
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Hypertriglyceridemia-induced Severe Necrotizing Pancreatitis Following Low Dose Tamoxifen Administration

Jang YH, Kim HJ

A 51-year-old woman visited the emergency room with severe abdominal pain of acute onset. She had undergone a breast cancer operation one year previously and had been taking a half-dose...
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Cell Division Cycle Associated 8 Is a Key Regulator of Tamoxifen Resistance in Breast Cancer

Yu D, Shi L, Bu Y, Li W

PURPOSE: Breast cancer (BC) is one of the most common malignancies globally, and millions of women worldwide are diagnosed with BC every year. Up to 70% of BC patients are...
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Uterine Malignant Mixed Müllerian Tumors Following Treatment with Selective Estrogen Receptor Modulators in Patients with Breast Cancer: A Report of 13 Cases and Their Clinicopathologic Characteristics

Jeong BK, Sung CO, Kim KR

BACKGROUND: Breast cancer treatment with selective estrogen receptor modulators (SERMs) increases the incidence of uterine malignant mixed Müllerian tumors (uMMMTs). We examine clinicopathologic characteristics and prognosis of SERM-associated uMMMTs (S-uMMMTs)...
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The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer

Lee S, Kim YH, Kim SC, Joo JK, Seo DS, Kim KH, Lee KS

OBJECTIVE: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. METHODS: We retrospectively reviewed the medical records of 309 women with breast cancer who were...
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Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction

Park JY, Chung JH, Lee HC, Lee BI, Park SH, Yoon ES

BACKGROUND: Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine...
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