Radiat Oncol J.  2014 Jun;32(2):77-83. 10.3857/roj.2014.32.2.77.

Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases

• Park JS
• Park HC
• Choi DH
• Park W
• Yu JI
• Park YS
• Kang WK
• Park JO

• KMID: 1842044
• DOI: http://doi.org/10.3857/roj.2014.32.2.77

Abstract

PURPOSE
To determine the prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases.
MATERIALS AND METHODS
Sixteen patients received whole liver radiotherapy (WLRT) between January 1997 and June 2013. A total dose of 21 Gy was delivered in 7 fractions.
RESULTS
The median survival time after WLRT was 9 weeks. In univariate analysis, performance status, serum albumin and total bilirubin level, liver volume and extrahepatic metastases were associated with survival. The mean liver volume was significantly different between subgroups with and without pain relief (3,097 and 4,739 mL, respectively; p = 0.002).
CONCLUSION
A larger liver volume is a poor prognostic factor for survival and also a negative predictive factor for response to WLRT. If patients who are referred for WLRT have large liver volume, they should be informed of the poor prognosis and should be closely observed during and after WLRT.

Keyword

Colorectal cancer; Metastasis; Liver; Tumor burden; Radiotherapy

MeSH Terms

Bilirubin
Colorectal Neoplasms*
Humans
Liver*
Neoplasm Metastasis*
Prognosis
Radiotherapy
Serum Albumin
Tumor Burden
Bilirubin
Serum Albumin