Nutr Res Pract.  2013 Oct;7(5):380-384. 10.4162/nrp.2013.7.5.380.

Dietary zinc intake is inversely associated with systolic blood pressure in young obese women

• Kim J

• KMID: 1841309
• DOI: http://doi.org/10.4162/nrp.2013.7.5.380

Abstract

Zinc may participate in blood pressure regulation and in the pathogenesis of hypertension. The study examined the relationship between zinc status and blood pressure in obese Korean women. Forty obese women (body mass index (BMI) > or = 25 kg/m2) aged 19-28 years participated in this study. Zinc intake was estimated from one 24 hour recall and 2-day diet records. Serum and urinary zinc concentrations were determined by atomic absorbance spectrophotometry. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using an automatic sphygmometer. Metabolic variables, such as waist circumference, triglyceride, high density lipoprotein (HDL) cholesterol, fasting glucose, and fasting insulin, were also measured. Dietary zinc intake of obese women was averagely 7.5 mg/day. Serum zinc and urinary zinc concentrations were 13.4 micromol/L and 378.7 microg/day, respectively. Averages of SBP and DBP were 119 mmHg and 78 mmHg. Dietary zinc intake was negatively correlated with SBP after adjusting for energy intake (P < 0.05), but serum and urinary zinc concentrations were not found to be correlated with SBP or DBP. Multivariate linear regression analysis showed that dietary zinc intake was inversely associated with SBP in obese women after adjusting for body weight, energy intake and sodium intake (P = 0.0145). The results show that dietary zinc intake may be an independent risk factor of elevated SBP in obese Korean women.

Keyword

Dietary zinc; blood pressure; body weight; obese Korean women

MeSH Terms

Aged
Blood Pressure
Body Weight
Cholesterol
Diet Records
Energy Intake
Fasting
Female
Glucose
Humans
Hypertension
Insulin
Linear Models
Lipoproteins
Risk Factors
Sodium
Spectrophotometry
Waist Circumference
Zinc
Cholesterol
Glucose
Insulin
Lipoproteins
Sodium
Zinc

Reference

1. Brown KH, Wuehler SE. Zinc and Human Health: Results of Recent Trials and Implications for Program Interventions and Research. Ottawa: Micronutrient Initiative;2000.

2. Prasad AS. Zinc: an overview. Nutrition. 1995; 11:93–99.

3. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993; 73:79–118.

4. Powell SR. The antioxidant properties of zinc. J Nutr. 2000; 130:1447S–1454S.

5. Hennig B, Wang Y, Ramasamy S, McClain CJ. Zinc deficiency alters barrier function of cultured porcine endothelial cells. J Nutr. 1992; 122:1242–1247.

6. Kok FJ, Van Duijn CM, Hofman A, Van der Voet GB, De Wolff FA, Paays CH, Valkenburg HA. Serum copper and zinc and the risk of death from cancer and cardiovascular disease. Am J Epidemiol. 1988; 128:352–359.

7. Reunanen A, Knekt P, Marniemi J, Mäki J, Maatela J, Aromaa A. Serum calcium, magnesium, copper and zinc and risk of cardiovascular death. Eur J Clin Nutr. 1996; 50:431–437.

8. Tubek S. Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertension. Biol Trace Elem Res. 2007; 117:39–51.

9. Tomat AL, Weisstaub AR, Jauregui A, Piñeiro A, Balaszczuk AM, Costa MA, Arranz CT. Moderate zinc deficiency influences arterial blood pressure and vascular nitric oxide pathway in growing rats. Pediatr Res. 2005; 58:672–676.

10. Bergomi M, Rovesti S, Vinceti M, Vivoli R, Caselgrandi E, Vivoli G. Zinc and copper status and blood pressure. J Trace Elem Med Biol. 1997; 11:166–169.

11. Sato M, Kurihara N, Moridaira K, Sakamoto H, Tamura J, Wada O, Yanagisawa H. Dietary Zn deficiency does not influence systemic blood pressure and vascular nitric oxide signaling in normotensive rats. Biol Trace Elem Res. 2003; 91:157–172.

12. Kurihara N, Yanagisawa H, Sato M, Tien CK, Wada O. Increased renal vascular resistance in zinc-deficient rats: role of nitric oxide and superoxide. Clin Exp Pharmacol Physiol. 2002; 29:1096–1104.

13. Taittonen L, Nuutinen M, Räsänen L, Mussalo-Rauhamaa H, Turtinen J, Uhari M. Lack of association between copper, zinc, selenium and blood pressure among healthy children. J Hum Hypertens. 1997; 11:429–433.

14. Marreiro DN, Fisberg M, Cozzolino SM. Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res. 2004; 100:137–149.

15. Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Viroonudomphol D, Vudhivai N, Schelp FP. Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. J Med Assoc Thai. 2003; 86:543–551.

16. Kim J, Jo I. Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults. Eur J Clin Nutr. 2010; 64:169–175.

17. Kim J, Kim HJ, Joung H, Park MK, Li S, Song Y, Franke AA, Paik HY. Overnight urinary excretion of isoflavones as an indicator for dietary isoflavone intake in Korean girls of pubertal age. Br J Nutr. 2010; 104:709–715.

18. Korean Nutrition Society. Dietary Reference Intake for Korean. Seoul: Kookjin Press;2005.

19. Kim J, Paik HY, Joung H, Woodhouse LR, King JC. Plasma zinc but not the exchangeable zinc pool size differs between young and older Korean women. Biol Trace Elem Res. 2011; 142:130–136.

20. American Society of Hypertension. Recommendations for routine blood pressure measurement by indirect cuff sphygmomanometry. American Society of Hypertension. Am J Hypertens. 1992; 5:207–209.

21. Kim J, Paik HY, Joung H, Woodhouse LR, Li S, King JC. Zinc supplementation reduces fractional zinc absorption in young and elderly Korean women. J Am Coll Nutr. 2004; 23:309–315.

22. Kim J, Paik HY, Joung H, Woodhouse LR, Li S, King JC. Effect of dietary phytate on zinc homeostasis in young and elderly Korean women. J Am Coll Nutr. 2007; 26:1–9.

23. Meret S, Henkin RI. Simultaneous direct estimation by atomic absorption spectrophotometry of copper and zinc in serum, urine, and cerebrospinal fluid. Clin Chem. 1971; 17:369–373.

24. Sato M, Yanagisawa H, Nojima Y, Tamura J, Wada O. Zn deficiency aggravates hypertension in spontaneously hypertensive rats: possible role of Cu/Zn-superoxide dismutase. Clin Exp Hypertens. 2002; 24:355–370.

25. Li H, Förstermann U. Nitric oxide in the pathogenesis of vascular disease. J Pathol. 2000; 190:244–254.

26. Moncada S. Nitric oxide in the vasculature: physiology and pathophysiology. Ann N Y Acad Sci. 1997; 811:60–67. discussion 7-9.

27. Vapaatalo H, Mervaala E, Nurminen ML. Role of endothelium and nitric oxide in experimental hypertension. Physiol Res. 2000; 49:1–10.

28. Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest. 2002; 109:817–826.

29. Dahlheim H, White CL, Rothemund J, von Lutterotti N, Jacob IC, Rosenthal J. Effect of zinc depletion on angiotensin I-converting enzyme in arterial walls and plasma of the rat. Miner Electrolyte Metab. 1989; 15:125–129.

30. Corti R, Burnett JC Jr, Rouleau JL, Ruschitzka F, Lüscher TF. Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease? Circulation. 2001; 104:1856–1862.