J Korean Soc Neonatol.  1998 Jun;5(1):40-44.

The effect of Large for Gestational Age on Asymmetrical Ventricular Septal Hypertrophy in the Newborn

• Kim YS
• Chae SA
• Lim IS
• Yoo BH

Abstract

PURPOSE: It has been known for a long time that infants of insulin dependent diabetic mothers are prone to develop macrosornia, organomegaly, hyperbilirubinemia, respiratory distress syndrome, hypoglycemia, hypocalcemia, septicemia and congenital anomalies in the neonatal period. And echocardiographic asymmetrical- ventricular septal hyper- trophy(ASH) has been observed in the newborn infants of diabetic mothers. The etiology of the ASH remains unknown, although fetal hyperglycemia and subsequent glycogen deposits have been postulated as contributing factors. Therefore, we have studied whether large for gestational age(LGA) has played an important role of developing ASH. METHODS: We compared echocardiographic findings in neonates of LGA and appro- priate for gestational age(AGA), who were admitted to the Department of Pediatrics, Chung Ang University Hospital from April 1994 to March 1997. RESULTS: 1) Mean LVED in LGA and AGA were 1.96+0.06cm and 1.94+0.04cm, respectively. 2) Mean LVPW in LGA and AGA were 0.37+0.05cm and 0.370.05cm, respectively. 3) Mean IVS in LGA and AGA were 0.400.09cm and 0.380.09cm, respectively. 4) Mean IVS/ LVPW in LGA and AGA were 1.09+0.12 and 1.040.17, respectively. There was no statistical significance between two groups in echocardiographic findings.
CONCLUSION
There is no relation between LGA and ASH in the neonate. According- ly, we may not need to perform echocardiography LGA routinely.

Keyword

Large for gestational age; Mean IVS/LVPW; Asymmetrical ventricular septal hypertrophy

MeSH Terms

Echocardiography
Gestational Age*
Glycogen
Humans
Hyperbilirubinemia
Hyperglycemia
Hypertrophy*
Hypocalcemia
Hypoglycemia
Infant
Infant, Newborn*
Insulin
Mothers
Pediatrics
Sepsis
Glycogen
Insulin