A Comparative Study of Left Ventricular Diastolic Function between Hypertrophic Cardiomyopathy and Hypertensive Patients with Left Ventricular Hypertrophy

Lee, Kyung Soon

Abstract

To evaluate the difference of left ventricular diastolic function between pathological hypertrophy(hypertrophic cardiomyopathy) and physiological hypertrophy(hypertensive heart). Doppler echocardiography was used to study mitral flow velocity in 17 hypertrophic cardiomyopathy without obstruction, 32 hypertensive patients with left ventricular hypertrophy and 15 normal persons. From the M-mode echocardopgraphic measurement, hypertensive patients were diviede into two groups;group I;asymmetrical septal hypertrophy, group II;symmetrical septal hypertrophy. Early and late diastolic peak velocity, the ratio of late to early diastolic peak flow velocity and deceleration of early diastolic flow were measured from Doppler mitral flow velocity recordings. The results were as follows; 1) There were significant difference in E velocity between hypertrophic cardiomyopathy and hypertensive patients. 2) There were no significant difference in A velocity between hypertrophy cardiomyopathy and hypertensive patients. 3) E/A ratio was significantly decreased in hypertrophic cardiomyopathy and group II hypertensive patients compared to group I hypertensive patients. 4) There were no significant difference in deceleration of early diastolic flow between groups. The study shows that the diastolic dysfunction of hypertrophic cardiomyopathy is more severe than hypertensive patients with left ventricular hypertrophy. The reason is probably due to the more extentive myopathic process in free wall of hypertrophic cardiomypathy than physiological ventricular hypertrophy.