Korean J Med.  2005 Jun;68(6):638-646.

Relationship of anemia and uric acid with clinical outcomes in congestive heart failure

• Han CH
• On YK
• Suh J
• Kim DH
• Bang DW
• Hyon MS
• Kim SK
• Kwon YJ

Abstract

BACKGROUND: Serum uric acid (UA) and anemia could be a valid and useful prognostic marker of chronic heart failure (CHF). We investigated the relationship of anemia and UA with clinical outcomes in CHF patients.
METHODS
We analyzed 109 patients with congestive heart failure between August 2001 and October 2002 (age 67 +/- 15 years, follow-up 14 +/- 5 months). We distributed the patients into 3 groups according to hematocrit (Hct) level [Hct group 1 (Hct <30%, n=21), Hct group 2 (Hct 30~38%, n=49), Hct group 3 (Hct >38%, n=39)] and into 3 groups according to serum uric acid (UA) level [UA group I (UA <5.2 mg/dL, n=20), UA group II (UA 5.2~7.5 mg/dL, n=25), UA group III (UA >7.5 mg/dL, n=20)]. Primary end point were rehospitalization resulting from aggravation of CHF and all-cause of death.
RESULTS
Among the groups according to Hct level, readmission rates were 57.1%, 28.6%, 15.4%, respectively (p<0.05). Among men, readmission rates were 82.3%, 22.2%, 14.3%, respectively (p<0.05). No significant difference in death rate was observed among the 3 groups. Among the groups according to UA level, there was no significant difference in readmission rates. Death rates were 5%, 8%, 35%, respectively (p<0.05) and there was significant difference in death rate especially among male patients.
CONCLUSION
In male patients, lower hematocrit level was associated with higher readmission rate and higher serum uric acid level was associated with death rate.

Keyword

Uric acid; Anemia; Heart failure

MeSH Terms

Anemia*
Estrogens, Conjugated (USP)*
Follow-Up Studies
Heart Failure*
Hematocrit
Humans
Male
Mortality
Uric Acid*
Estrogens, Conjugated (USP)
Uric Acid