Korean J Med.  2003 Jul;65(1):22-31.

IL-1beta and IL-1RN polymorphisms in gastroduodenal diseases

• Lee JH
• Kim GH
• Heo J
• Park DY
• Jun ES
• Kang DH
• Song GA
• Cho M
• Yang US

Abstract

BACKGROUND: IL-1beta and IL-1 receptor antagonist (IL-1RN) genetic polymorphisms have been associated with development of gastric atrophy and increased risk of gastric carcinoma. This study aimed to determine the effects of these polymorphisms in gastroduodenal diseases.
METHODS
This study population was comprised of 297 patients and they were grouped into gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. We determined IL-1beta-511/-31/+3954 and IL-1RN genotype by polymerase chain reaction using gastric biopsy specimens.
RESULTS
The genotype of IL-1beta-511 C/T, -31 T/C, +3954 C/C, and IL-1RN *1/*1 was predominant in all four groups. Allelic and genotypic frequencies of IL-1beta-511/-31/+3954 and IL-1RN showed no significant difference in four groups. IL-1beta-511 T/T, -31 C/C, +3954 C/T, and IL-1RN *2 carriers did not show increased risk of gastric ulcer, duodenal ulcer and gastric cancer. Classification of gastric cancer into intestinal and diffuse type also showed no significant difference of IL-1beta-511/-31/+3954 and IL-1RN genotypic frequencies. CONCLSUION: There was no significant difference of IL-1beta and IL-1RN polymorphisms between patients with gastritis, gastric ulcer, duodenal ulcer and gastric cancer. Therefore, other endogenous or exogenous factors will play more important role in the development of gastroduodenal diseases in Korean.

Keyword

Interleukin-1; Polymorphism; Gastroduodenal diseases

MeSH Terms

Atrophy
Biopsy
Classification
Duodenal Ulcer
Gastritis
Genotype
Humans
Interleukin-1
Polymerase Chain Reaction
Polymorphism, Genetic
Stomach Neoplasms
Stomach Ulcer
Interleukin-1