J Korean Radiol Soc.  2002 Feb;46(2):171-174. 10.3348/jkrs.2002.46.2.171.

CT and MR Findings of Langerhans Cell Histiocytois Involving the Spleen: A Case Report

• Pyun HW
• Kim ME
• Kim JH

• KMID: 1832982
• DOI: http://doi.org/10.3348/jkrs.2002.46.2.171

Abstract

Langerhans cell histiocytosis (LCH) is systemic disease resulting from the proliferation and dissemination of abnormal histiocytic cells of the Langerhans cell system. Common sites of involvement include the skin, bone, bone marrow, lung, lymph nodes and central nervous system, and the condition manifests in a variety of ways. We present the CT and MR findings of a case of LCH involving the spleen, an organ involved relatively rarely. Post-contrast CT revealed multiple hypodense nodules. T1-weighted MR images of the spleen depicted no definitive lesion, but T2-weighted images showed abnormal low signals scattered throughout this organ. In addition, post-contrast, fat-saturated T1-weighted MR images lesions showed multiple, low-signal-intensity lesions.

Keyword

Children, lymphatic system; Spleen, MR; Histiocytosis

MeSH Terms

Bone Marrow
Central Nervous System
Histiocytosis
Histiocytosis, Langerhans-Cell
Lung
Lymph Nodes
Skin
Spleen*