Korean J Fertil Steril.  2006 Jun;33(2):85-95.

Association of the CYP1B1 Gene Polymorphism with the Risk of Advanced Endometriosis in Korean Women

Affiliations
  • 1Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, College of Medicine, Konyang University, Daechon, Korea.
  • 3Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea. hyewon@ewha.ac.kr

Abstract


OBJECTIVE
To investigate whether polymorphisms of gene encoding CYP1B1 is associated with the risk of endometriosis in Korean women.
METHODS
We investigated 199 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 183 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at G119-T, G432-C, T449-C, and A453-G were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products.
RESULTS
We found no overall association between each individual CYP1B1 genotype and the risk of endometriosis. The odds ratio of genotype GG/GC+GG/TC+TT/AA compared to GG/CC/CC/AA (reference) was calculated as 2.06 with a 95% confidence interval of 1.003~4.216.
CONCLUSIONS
This results suggest that CYP1B1 genetic polymorphism may be associated with development of endometriosis in Korean women.

Keyword

Endometriosis; CYP1B1; Genetic polymorphism

MeSH Terms

Endometriosis*
Female
Genotype
Humans
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
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