Korean J Clin Microbiol.  2009 Sep;12(3):141-143. 10.5145/KJCM.2009.12.3.141.

Myositis due to Cryptococcus neoformans in a Diabetic Patient

• Heo ST
• Bae IG
• Park JY
• Kim SJ

• KMID: 1828586
• DOI: http://doi.org/10.5145/KJCM.2009.12.3.141

Abstract

We report a rare case of cryptococcal myositis with dissemination to lung in a 66-year-old diabetic woman who had no apparent risk factors for cryptococcal disease. She visited the hospital with a continuous pain in the right thigh and fever despite of treatment with antibiotics. She developed a localized lung infiltration. Crytococcus neoformans was isolated from the abscess of the right thigh and confirmed by molecular identification with DNA sequence analysis. Biopsy of the involved lung showed numerous budding yeasts consistent with Cryptocococcus species. The patient was successfully treated with surgical drainage and systemic antifungal agents.

Keyword

Cryptococcus neoformans; Myositis; Diabetes mellitus; Sequence analysis

MeSH Terms

Abscess
Aged
Anti-Bacterial Agents
Biopsy
Cryptococcus
Cryptococcus neoformans
Diabetes Mellitus
Drainage
Female
Fever
Humans
Lung
Myositis
Risk Factors
Saccharomycetales
Sequence Analysis
Sequence Analysis, DNA
Thigh
Anti-Bacterial Agents

Figure

• 

  Fig. 1. Enhanced CT of the patient's lower extremity reveals swelling of the right gluteus medius muscle and fluid collection (arrow) between the fascia lata and vastus muscle. There is no evidence of bone involvement.

• 

  Fig. 2. Lung biopsy specimen shows variable sized, small round fungal spores with surrounding clear halo (arrow head). Most spores are found within giant cells in granulomas (arrow) (Gomori methenamine silver (GMS) stain, original magnification ×400).

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