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Cutaneous Manifestation of Disseminated Cryptococcosis Mimicking Herpes Zoster

Choi H, Shim DH, Kim MS, Shin BS, Na CH

Cutaneous cryptococcosis is classified either as localized cutaneous cryptococcosis, in which the lesions are confined to one area of the skin, or as disseminated cryptococcosis, in which cutaneous manifestations are...
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Disseminated Cryptococcosis Incorrectly Managed: a Case Report

Maleb A, Hami A, Ben Lahlou Y, Lamrabat S, Rifai S, Rahmani N, Bensalah M, Frikh M, Lemnouer A, Elouennass M

Disseminated cryptococcosis is a rare fungal infection, which mainly occurs in immunocompromised patients, and the diagnosis is difficult. Therefore, it is less likely to be considered in immunocompetent patients. Here,...
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Mon1 Is Essential for Fungal Virulence and Stress Survival in Cryptococcus neoformans

Son YE, Jung WH, Oh SH, Kwak JH, Cardenas M, Park HS

Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized...
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Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis

Choi J, Kim SH

Cryptococcus neoformans is the most common microorganism found in cerebrospinal fluid (CSF) cytology and causes life-threatening infections in immunocompromised hosts. Although its cytomorphologic features in conventional smear cytology have been...
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Genotypes of Clinical and Environmental Isolates of Cryptococcus neoformans and Cryptococcus gattii in Korea

Park SH, Choi SC, Lee KW, Kim MN, Hwang SM

Multilocus sequence typing analysis was applied to determine the genotypes of 147 (137 clinical and 10 environmental) Cryptococcus neoformans and three clinical Cryptococcus gattii isolates from 1993 to 2014 in...
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Cryptococcus neoformans Cellulitis with Cryptococcemia in a Patient on Maintenance Hemodialysis

Jeong IW, Kim JE, Kim SH, Kim JH, Hong YA, Ko GJ, Kwon YJ

Cryptococcus neoformans is a fungus that causes opportunistic infections in immunocompromised hosts. Skin lesions are found in 10-20% of systemic cryptococcal infections, usually secondary to cryptococcemia, while primary cutaneous cryptococcosis...
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Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans

Kim J, Park M, Do E, Jung WH

Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the...
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A Ferroxidase, Cfo1, Regulates Diverse Environmental Stress Responses of Cryptococcus neoformans through the HOG Pathway

Lee KT, Lee JW, Lee D, Jung WH, Bahn YS

  • KMID: 2312738
  • Mycobiology.
  • 2014 Jun;42(2):152-157.
The iron uptake and utilization pathways play a critical role in allowing human pathogens, including Cryptococcus neoformans, the causative agent of fatal meningoencephalitis, to survive within the mammalian body by...
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Molecular Epidemiology of Clinical Cryptococcus neoformans Isolates in Seoul, Korea

Park SH, Kim M, Joo SI, Hwang SM

  • KMID: 2312726
  • Mycobiology.
  • 2014 Mar;42(1):73-78.
Cryptococcal infection is primarily caused by two species, Cryptococcus neoformans and C. gattii. Between the two species, C. neoformans var. grubii is the major causative agent of cryptococcosis in Asia....
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A Nudix Hydrolase Protein, Ysa1, Regulates Oxidative Stress Response and Antifungal Drug Susceptibility in Cryptococcus neoformans

Lee KT, Kwon H, Lee D, Bahn YS

  • KMID: 2312723
  • Mycobiology.
  • 2014 Mar;42(1):52-58.
A nucleoside diphosphate-linked moiety X (Nudix) hydrolase-like gene, YSA1, has been identified as one of the gromwell plant extract-responsive genes in Cryptococcus neoformans. Ysa1 is known to control intracellular concentrations...
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Lipolytic Enzymes Involved in the Virulence of Human Pathogenic Fungi

Park M, Do E, Jung WH

  • KMID: 2312689
  • Mycobiology.
  • 2013 Jun;41(2):67-72.
Pathogenic microbes secrete various enzymes with lipolytic activities to facilitate their survival within the host. Lipolytic enzymes include extracellular lipases and phospholipases, and several lines of evidence have suggested that...
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Molecular Typing of Cryptococcus neoformans Isolated from Korean Patients

Park SH, Cho SI, Hwang SM

Cyptococcosis is generally caused by Cryptococcus neoformans, the opportunistic agent which has two species such as C. neoformans and C. gattii. Both C. neoformans and C. gattii species contain a...
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Primary Cutaneous Cryptococcosis in a Patient with Iatrogenic Cushing's Syndrome: A Case Report and Review of the Literature

Ko YJ, Hong MH, Park CM, Moon HW, Hur M, Yun YM

Cryptococcus neoformans (C. neoformans) is a ubiquitous yeast-like fungus that has been a common opportunistic human pathogen, especially in immunocompromised patients. Although skin lesions due to C. neoformans are found...
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A Case of Mediastinal and Pulmonary Cryptococcosis in a 3-Year-Old Immunocompetent Girl

Lee HS, Park HB, Kim KW, Sohn MH, Kim KE, Kim MJ, Cho SH

  • KMID: 2315162
  • Pediatr Allergy Respir Dis.
  • 2011 Dec;21(4):350-355.
Cryptococcosis is an infrequently recognized infection in children, particularly those who are immunocompetent. The disease is mainly caused by Cryptococcus neoformans, a fungal pathogen that primarily affects the central nervous...
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pH Response Pathways in Fungi: Adapting to Host-derived and Environmental Signals

Selvig K, Alspaugh J

  • KMID: 2312650
  • Mycobiology.
  • 2011 Dec;39(4):249-256.
Microorganisms are significantly affected when the ambient pH of their environment changes. They must therefore be able to sense and respond to these changes in order to survive. Previous investigators...
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The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi

Liu TB, Xue C

  • KMID: 2312649
  • Mycobiology.
  • 2011 Dec;39(4):243-248.
The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating...
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Two Cases of Cryptococcuria Developed as Isolated Cryptococcuria and Disseminated Cryptococcosis

Bae MH, Namgoong S, An D, Kim MN, Kim SH, Park KH, Lee SG

Cryptococcus is an opportunistic pathogen that mainly affects immunocompromised hosts and, less frequently, immunocompetent hosts. It causes serious morbidity and mortality due to systemic infections such as meningoencephalitis and pulmonary...
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The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans

Kronstad J, Hu G, Choi J

  • KMID: 2312633
  • Mycobiology.
  • 2011 Sep;39(3):143-150.
The basidiomycete fungus Cryptococcus neoformans is an important pathogen of immunocompromised people. The ability of the fungus to sense its environment is critical for proliferation and the generation of infectious...
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A Case of Cryptococcal Abscess Involving Deep Neck Space in an Immunocompetent Patient

Park SW, Choi JY, Kim AY, Chang DS

The encapsulated yeast, Cryptococcus, has rapidly risen to a worldwide major opportunistic fungal pathogen. Infection with Cryptococcus neoformans usually occurs in immunocompromised host and but may occur also occur in...
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Five Cases of Pulmonary Cryptococcosis in Immunocompetent Patients

Oh HJ, Choi MY, Kim SH, Song EM, Baek DH, Kim JH, Ryu YJ, Chun EM, Lee JH, Chang JH, Shim SS

Cryptococcal infections occur frequently in patients with cell-mediated immune deficiency, such as acquired immune deficiency syndrome, organ transplants, hematologic malignancy patients and immunocompromised patients who receiving cancer chemotherapy or corticosteroid...
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