J Korean Acad Rehabil Med.
2006 Apr;30(2):135-141.
Relevance of Behavioral Test in the Photothrombotic Stroke Rat Model
- Affiliations
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- 1Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Korea. cbrmshin@wonkwang.ac.kr
- 2Department of Neurosurgery, Wonkwang University School of Medicine, Korea.
- 3Department of Pharmacology, Wonkwang University School of Medicine, Korea.
- 4Department of Neurosurgery, Presbyterian Medical Center, Korea.
- 5Department of Internal Medicine, Wonkwang University College of Oriental Medicine, Korea.
- 6Department of Pathology, Chonnam National University, School of Medicine, Korea.
Abstract
OBJECTIVE
The purpose of this study was to find reliable behavioral measures for the evaluation of motor dysfunction in photothrombotic ischemia rat model. METHOD: Male Sprague-Dawley rats were trained for behavioral test including tray reaching task (TRT), single pellet reaching task (SPRT), and rotarod task (RRT) for more than 2 weeks. Photothrombotic ischemia was induced in a stereotactically held rats using Rose Bengal dye (20 mg/kg) and cold light. Rats were assigned to either control (n=10) or experimental ischemic group (n=10). Post-lesional behavioral tests were performed for 4 weeks after confirmation of lesion by magnetic resonance imaging (MRI), followed by histological examination.
RESULTS
RRT showed no difference between control and experimental group. SPRT and TRT showed significant difference between control and experimental group (p<0.05). SPRT could well demonstrate the recovery of motor dysfunction after over time.
CONCLUSION
SPRT could be the most reliable test to measure not only motor dysfunction but also motor recovery in unilateral motor cortex lesion of photothrombotic ischemia rat model.
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