Infect Chemother.  2004 Dec;36(6):350-356.

Drug Use Evaluation of Intravenous Ciprofloxacin in University Hospitals in Korea

• Kim SW
• Park HJ
• Oh WS
• Kim YS
• Chang HH
• Jung SI
• Chung DR
• Lee H
• Yeom JS
• Ki HK
• Son JS
• Peck KR
• Woo GJ
• Song JH

Abstract

BACKGROUND: To evaluate the appropriateness of intravenous (IV) ciprofloxacin usage in university hospitals in Korea.
MATERIALS AND METHODS
We prospectively evaluated the appropriateness of drug usage in 290 consecutive adult patients who received IV ciprofloxacin in eight teaching hospitals during the period from September 25, 2003 to November 15, 2003. Drug use evaluation (DUE) in this study was based on the modified standard by the American Society of Hospital Pharmacy with regard to the justification of drug use, critical and process indications, complications, and outcome measures.
RESULTS
Average age of the patients was 54 years. The use of IV ciprofloxacin was appropriate only in 33 cases (26.9%). Common reasons for inappropriate use of IV ciprofloxacin include perioperative uses or prophylactic injection before urologic procedures, and empirical therapy for febrile episodes. Most of the "critical indications" and "process indications" showed high rate of appropriateness (82.4-100%). However, the rate of taking culture and sensitivity test before (73.8%) and during ciprofloxacin use (68.6%) were low. Complications with ciprofloxacin use were rare. In 93.3% of cases, ciprofloxacin treatment was clinically effective.
CONCLUSION
Use of intravenous ciprofloxacin is frequently inappropriate in tertiary care hospitals in Korea. Implementation of education program and antibiotic control system is critical in improving the appropriateness of antimicrobial use.

Keyword

Drug use evaluation; Ciprofloxacin

MeSH Terms

Adult
Ciprofloxacin*
Education
Hospitals, Teaching
Hospitals, University*
Humans
Korea*
Outcome Assessment (Health Care)
Pharmacy
Prospective Studies
Tertiary Healthcare
Ciprofloxacin