Infect Chemother.  2004 Feb;36(1):40-45.

Analysis of Invasive Fungal Infection after Hematopoietic Stem Cell Transplantation or Chemotherapy in Patients with Hematologic Diseases

• Yoo JH
• Choi JH
• Lee DG
• Choi S
• Shin WS
• Kim CC

Abstract

BACKGROUND: Invasive fungal infections (IFI) are one type of representing total infections in compromised patients. To analyze the characteristics and to determine the prognostic factors of IFI in patients with hematologic diseases undergoing hematopoietic stem cell transplantation (HSCT) and/or chemotherapy.
METHODS
We retrospectively reviewed consecutive patients (n=122) who received antifungal treatment with the impression of fungal infection complicating post-HSCT or chemotherapy from March- 2000 to February-2001.
RESULTS
Seventy-four out of 122 registered patients belonged to the IFI on the basis of EORTC/ MSG criteria. Six patients were proven IFI, 46 were probable, and 22 were in the category of possible one. The most commonly involved organ was lower respiratory tract (72/74). The mortality was 32.4%. Univariate analysis revealed duration of hospitalization, days to diagnosis of IFI, and total amount of amphotericin B as significant prognostic factors. But multivariate analysis determined only duration of hospitalization from these variables as an independently influencing factor on the prognosis.
CONCLUSION
Invasive fungal infection is still the major threatening complication of HSCT and chemotherapy. Further follow-up and extension of this study is necessary to elucidate more prognostic factors.

Keyword

Invasive fungal infection; Immunocompromised

MeSH Terms

Amphotericin B
Diagnosis
Drug Therapy
Follow-Up Studies
Hematologic Diseases*
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Hospitalization
Humans
Mortality
Multivariate Analysis
Prognosis
Respiratory System
Retrospective Studies
Sodium Glutamate
Amphotericin B
Sodium Glutamate