Intest Res.  2015 Jan;13(1):74-79. 10.5217/ir.2015.13.1.74.

Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas

• Song YK
• Park YS
• Seon CS
• Lim HJ
• Son BK
• Ahn SB
• Jo YK
• Kim SH
• Jo YJ
• Lee JH
• Kim SC

• KMID: 1807379
• DOI: http://doi.org/10.5217/ir.2015.13.1.74

Abstract

BACKGROUND/AIMS
Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.
METHODS
Patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.
RESULTS
212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.
CONCLUSIONS
This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.

Keyword

Advanced colorectal adenoma; Alcohol drinking; Risk; Liver diseases, alcoholics

MeSH Terms

Adenoma*
Alcohol Drinking*
Colonic Neoplasms
Gastroenterology
Hematologic Tests
Humans
Life Style
Liver Diseases, Alcoholic
Odds Ratio
Tomography, X-Ray Computed
Ultrasonography

Figure

• 

  Fig. 1 Analysis chart of this study.

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