Vasc Spec Int.
2015 Mar;31(1):1-10. 10.5758/vsi.2015.31.1.1.
Recent Advances in the Development of Experimental Animal Models Mimicking Human Aortic Aneurysms
- Affiliations
-
- 1Department of Surgery, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea.
- 2Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. tslee@snubh.org
- 3Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 1803151
- DOI: http://doi.org/10.5758/vsi.2015.31.1.1
Abstract
- Aortic aneurysm is a common and life-threatening disease that can cause death from rupture. Current therapeutic options are limited to surgical or endovascular procedures because no pharmacological approaches have been proven to decrease the chance of expansion or rupture. The best approach to the management of aortic aneurysm would be the understanding and prevention of the processes involved in disease occurrence, progression, and rupture. There is a need for animal models that can reproduce the pathophysiological features of human aortic aneurysm, and several such models have been studied. This review will emphasize recent advances in animal models used in the determination of mechanisms and treatments of aortic aneurysms.
