J Korean Med Sci.  2014 Jan;29(1):117-121. 10.3346/jkms.2014.29.1.117.

Chlorogenic Acid Supplementation Improves Multifocal Electroretinography in Patients with Retinitis Pigmentosa

• Shin JY
• Yu HG

• KMID: 1796924
• DOI: http://doi.org/10.3346/jkms.2014.29.1.117

Abstract

To evaluate the effect of chlorogenic acid supplementation in patients with retinitis pigmentosa, we evaluated objective change in visual function with multifocal electroretinography, along with visual acuity, visual field, standard electroretinography, and contrast sensitivity. Eighteen patients diagnosed with retinitis pigmentosa were enrolled in this prospective, non-comparative, single-arm study. Multifocal electroretinography, best-corrected visual acuity in Early Treatment Diabetic Retinopathy Study letters, total point score on visual field examination with Humphrey Field Analyzer II, electroretinography, and contrast sensitivity were measured and repeated after 3 months supplementation with chlorogenic acid. The amplitude of ring 5 was significantly higher on multifocal electroretinography after 3 months of chlorogenic acid supplementation (7.2 +/- 9.5 vs 8.3 +/- 10.8 nV/deg2, mean +/- standard deviation, P = 0.022). There were no significant changes in the best-corrected visual acuity, total point score on Humphrey Field Analyzer, 30 Hz flicker amplitude on standard electroretinography, or contrast sensitivity. Chlorogenic acid may have a beneficial effect on the peripheral area at the margins of retinal degeneration, and should be considered as an anti-oxidant for the management of retinitis pigmentosa.

Keyword

Retinitis Pigmentosa; Chlorogenic Acid; Oxidative Stress; Antioxidants; Retinal Degeneration

MeSH Terms

Adult
Antioxidants/adverse effects/therapeutic use
Chlorogenic Acid/adverse effects/*therapeutic use
Dietary Supplements/adverse effects
Electroretinography/*drug effects
Female
Humans
Male
Middle Aged
Oxidative Stress/drug effects
Prospective Studies
Retina/physiopathology
Retinitis Pigmentosa/*drug therapy
Vision, Ocular/*drug effects
Visual Acuity/*drug effects
Visual Fields/drug effects
Young Adult
Antioxidants
Chlorogenic Acid

Figure

• 

  Fig. 1 A comparison of amplitude on multifocal electroretinography before and after CGA supplementation. *P < 0.05. CGA, chlorogenic acid.

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