J Korean Med Sci.  2010 Dec;25(12):1766-1770. 10.3346/jkms.2010.25.12.1766.

Association of Renal Manifestations with Serum Uric Acid in Korean Adults with Normal Uric Acid Levels

• Jung DH
• Lee YJ
• Lee HR
• Lee JH
• Shim JY

• KMID: 1792901
• DOI: http://doi.org/10.3346/jkms.2010.25.12.1766

Abstract

Several studies have reported that hyperuricemia is associated with the development of hypertension and cardiovascular disease. Increasing evidences also suggest that hyperuricemia may have a pathogenic role in the progression of renal disease. Paradoxically, uric acid is also widely accepted to have antioxidant activity in experimental studies. We aimed to investigate the association between glomerular filtration rate (GFR) and uric acid in healthy individuals with a normal serum level of uric acid. We examined renal function determined by GFR and uric acid in 3,376 subjects (1,896 men; 1,480 women; aged 20-80 yr) who underwent medical examinations at Gangnam Severance Hospital from November 2006 to June 2007. Determinants for renal function and uric acid levels were also investigated. In both men and women, GFR was negatively correlated with systolic and diastolic blood pressures, fasting plasma glucose, total cholesterol, uric acid, log transformed C reactive protein, and log transformed triglycerides. In multivariate regression analysis, total uric acid was found to be an independent factor associated with estimated GFR in both men and women. This result suggests that uric acid appears to contribute to renal impairment in subjects with normal serum level of uric acid.

Keyword

Glomerular Filtration Rate; Uric Acid; Antioxidants

MeSH Terms

Adult
Age Factors
Aged
Aged, 80 and over
Blood Glucose/analysis
Blood Pressure
Cholesterol/blood
Female
Glomerular Filtration Rate
Humans
Hyperuricemia/blood/etiology
Kidney Diseases/*blood/etiology
Male
Middle Aged
Regression Analysis
Republic of Korea
Risk Factors
Uric Acid/*blood

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