Korean J Hepatol.  2010 Jun;16(2):176-181. 10.3350/kjhep.2010.16.2.176.

Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. dyk1025@yuhs.ac
  • 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.

Keyword

Portal hypertension; Thrombosis; Protein C deficiency; Protein S deficiency

MeSH Terms

Humans
Hypertension, Portal/complications/*diagnosis/pathology
Male
*Portal Vein
Protein C Deficiency/*complications
Protein S Deficiency/*complications
Tomography, X-Ray Computed
Venous Thrombosis/complications/*diagnosis/pathology
Young Adult
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