Korean J Hepatol.
2010 Jun;16(2):176-181. 10.3350/kjhep.2010.16.2.176.
Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. dyk1025@yuhs.ac
- 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 1792596
- DOI: http://doi.org/10.3350/kjhep.2010.16.2.176
Abstract
- Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
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