Ann Pediatr Endocrinol Metab.  2015 Mar;20(1):13-20. 10.6065/apem.2015.20.1.13.

Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus

• Son MK
• Yoo HY
• Kwak BO
• Park HW
• Kim KS
• Chung S
• Chae HW
• Kim HS
• Kim DH

• KMID: 1789526
• DOI: http://doi.org/10.6065/apem.2015.20.1.13

Abstract

PURPOSE
Although microalbuminuria is considered as an early marker of nephropathy in diabetic adults, available information in diabetic adolescents is limited. The aim of this study was to investigate prevalence and frequency of regression of microalbuminuria in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) patients with childhood onset.
METHODS
One hundred and nine adolescents (median, 18.9 years; interquartile range (IQR), 16.5-21.0 years) with T1DM and 18 T2DM adolescents (median, 17.9 years; IQR, 16.8-18.4 years) with repeated measurements of microalbuminuria (first morning urine microalbumin/creatinine ratios) were included. The median duration of diabetes was 10.1 (7.8-14.0) years and 5.0 (3.5-5.6) years, respectively, and follow-up period ranged 0.5-7.0 years. Growth parameters, estimated glomerular filtration rate, glycosylated hemoglobin (HbA1c) and lipid profiles were obtained after reviewing medical record in each subject.
RESULTS
The prevalence of microalbuminuria at baseline and evaluation were 21.1% and 17.4% in T1DM, and 44.4% and 38.9% in T2DM. Regression of microalbuminuria was observed in 13 T1DM patients (56.5%) and 3 T2DM patients (37.5%), and progression rate was 10.5% and 20% in T1DM and T2DM respectively. In regression T1DM group, HbA1c at baseline and follow-up was lower, and C-peptide at baseline was higher compared to persistent or progression groups. In T2DM, higher triglyceride was observed in persistent group.
CONCLUSION
Considerable regression of microalbuminuria more than progression in diabetes adolescents indicates elevated urinary microalbumin excretion in a single test does not imply irreversible diabetic nephropathy. Careful monitoring and adequate intervention should be emphasized in adolescents with microalbuminuria to prevent rapid progression toward diabetic nephropathy.

Keyword

Albuminuria; Type 1 diabetes mellitus; Type 2 diabetes mellitus; Child; Adolescent

MeSH Terms

Adolescent*
Adult
Albuminuria
C-Peptide
Child
Diabetes Mellitus*
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Follow-Up Studies
Glomerular Filtration Rate
Hemoglobin A, Glycosylated
Humans
Medical Records
Prevalence
Triglycerides
C-Peptide

Figure

• 

  Fig. 1 Schematic representation of diabetic patients with persistent, regression, and progression groups to microalbuminuria. T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus.

• 

  Fig. 2 Comparison of spot urine microalbumin/creatinine ratio between baseline and follow-up assessment. The median is depicted by the horizontal line, the interquartile range by the box limits, ranges by the whiskers, and outliers by the circles.

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