J Korean Med Sci.
2013 Apr;28(4):516-521. 10.3346/jkms.2013.28.4.516.
Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy
- Affiliations
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- 1Department of Pediatrics, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.
- 2Department of Occupational and Environmental Medicine, Dongguk University-Seoul, Graduate School of Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.
- 3Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.
- 4Medical Research Institute, Ewha Global Challenge Center, Ewha Womans University, Seoul, Korea.
- 5Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 6Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 7Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.
- 8Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.
- 9Department of Occupational and Environmental Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea. yanghokm@nuri.net
- KMID: 1786957
- DOI: http://doi.org/10.3346/jkms.2013.28.4.516
Abstract
- Our objective was to evaluate the relationship between intrauterine exposure to cadmium and the presence of atopic dermatitis in infants 6 months of age, adjusted for covariates including exposure to other heavy metals. The present research is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project conducted in Korea. Study subjects were restricted to pregnant women in whom cadmium and lead levels were measured at delivery and whose infants were assessed for the presence of atopic disease at 6 months of age. The odds ratio (OR) for the presence of atopic dermatitis in 6-month-old infants whose cord blood had elevated cadmium levels, after adjustment for other covariates, was 2.350 (95% CI, 1.126-4.906). The OR for the presence of atopic dermatitis in infants whose cord blood had elevated lead levels was not significant. In the present study, the cord blood cadmium level was significantly associated with the presence of atopic dermatitis in 6-month-old infants; this was not true of the cord blood lead level. To the best of our knowledge, this is the first prospective study to show a relationship between prenatal exposure to cadmium and atopic dermatitis in infancy.
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