J Vet Sci.  2014 Jun;15(2):267-271. 10.4142/jvs.2014.15.2.267.

Use of aglepristone for the treatment of P4 induced insulin resistance in dogs

• Bigliardi
• Bresciani
• Callegari
• Di Ianni F
• Morini G
• Parmigiani E
• Bianchi E

• KMID: 1784648
• DOI: http://doi.org/10.4142/jvs.2014.15.2.267

Abstract

Insulin resistance (IR) in dogs is suspected when hyperglycemia is present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR is caused by increases in counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted to investigate the use of aglepristone (RU 46534), a P4 receptor antagonist, for the treatment of IR diabetes mellitus in bitches during the luteal phase. All animals were treated with porcine insulin zinc suspension (Caninsulin) and aglepristone (Alizin) 10 mg/kg subcutaneously at day 1, 2, 9 and 17 from diagnosis. At day 5, no significant variation in glycemia was shown. At day 12 and 20, serum glucose concentrations were significant lower (p < 0.05). From day 12 the insulin dose was reduced to 0.8 IU BID. Insulin was reduced in the following weeks and glycemia was controlled.

Keyword

aglepristone; bitches; diabetes mellitus; diestrus; insulin resistance

MeSH Terms

Animals
Blood Glucose/analysis
Diabetes Mellitus/drug therapy/etiology/*veterinary
Dog Diseases/*drug therapy/etiology
Dogs
Estrenes/*therapeutic use
Estrous Cycle
Female
Hypoglycemic Agents/therapeutic use
Insulin Resistance
Pregnancy
Radioimmunoassay/veterinary
Receptors, Progesterone/*antagonists & inhibitors
Blood Glucose
Estrenes
Hypoglycemic Agents
Receptors, Progesterone

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