Korean J Lab Med.  2010 Jun;30(3):203-217. 10.3343/kjlm.2010.30.3.203.

New HLA Nomenclature (2010) and Its Clinical Application in Koreans

• Lee KW
• Park MH

• KMID: 1781617
• DOI: http://doi.org/10.3343/kjlm.2010.30.3.203

Abstract

Human leukocyte antigen (HLA) gene region encodes a set of HLA molecules functioning critical roles in immune response. Each HLA gene locus shows extensive polymorphism with ever-increasing number of alleles. The HLA nomenclature system for alleles defined by DNA typing was first established in 1987 and has been revised several times. Recently, it has been revised again with a new frame that can accommodate ever-increasing number of new alleles. The new system has also introduced the novel suffixes, P and G, to simplify reporting of ambiguous strings of alleles in typing reports. This review introduces the HLA nomenclature system-2010 in conjunction with its clinical application in Koreans.

Keyword

Human leukocyte antigen; Nomenclature; Korea

MeSH Terms

Alleles
Asian Continental Ancestry Group/*genetics
HLA Antigens/classification/*genetics
Humans
Republic of Korea
*Terminology as Topic

Figure

• 

  Fig. 1. Fig. 1. Example of an HLA allele name with description (Nomenclature-2010). Illustration in bracket [] provides information on each field of the nomenclature, A∗01:01:01:02N.

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  Fig. 2. Example of HLA allele names converted from old to new version of the nomenclature. (A) General examples of name conversion for HLA-A, -B, -DRB1, and -DQB1 alleles. (B) Examples of name conversion for A∗92 and B∗95 allele families. (C) Examples of name conversion for DPB1 alleles. (D) Examples of name conversion for C alleles.

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