Ann Lab Med.  2013 Sep;33(5):375-378. 10.3343/alm.2013.33.5.375.

Repeated Serum Alkaline Phosphatase Measurements in the Treatment of Childhood Acute Bone and Joint Infections with High Doses of Antibiotics

Affiliations
  • 1Division of Diseases of the Musculoskeletal System, Turku University Hospital and University of Turku, Turku, Finland. Markus.Paakkonen@helsinki.fi
  • 2Department of Paediatrics, University of Helsinki and Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland.

Abstract

No abstract available.


MeSH Terms

Acute Disease
Adolescent
Alkaline Phosphatase/*blood
Anti-Bacterial Agents/*therapeutic use
Arthritis, Infectious/*drug therapy/*enzymology/microbiology
*Bacterial Infections/drug therapy/enzymology/microbiology
Child
Child, Preschool
Haemophilus influenzae type b/isolation & purification
Humans
Infant
Osteomyelitis/*drug therapy/*enzymology/microbiology
Staphylococcus aureus/isolation & purification
Streptococcus pneumoniae/isolation & purification
Streptococcus pyogenes/isolation & purification
Anti-Bacterial Agents
Alkaline Phosphatase

Figure

  • Fig. 1 (A) Alkaline phosphatase levels in patients with osteomyelitis (N=106) versus patients with septic arthritis (N=134). (B) Alkaline phosphatase levels in patients given clindamycin (N=99) versus first-generation cephalosporin (N=70).Abbreviation: ALP, alkaline phosphatase.


Reference

1. Warnes TW. Alkaline phosphatase. Gut. 1972; 13:926–937. PMID: 4566959.
Article
2. Corathers SD. Focus on diagnosis: the alkaline phosphatase level: nuances of a familiar test. Pediatr Rev. 2006; 27:382–384. PMID: 17012488.
Article
3. Peltola H, Pääkkönen M, Kallio P, Kallio MJ. OM-SA Study Group. Clindamycin vs. first-generation cephalosporins for acute osteoarticular infections of childhood --a prospective quasi-randomized controlled trial. Clin Microbiol Infect. 2012; 18:582–589. PMID: 22011265.
4. Naal FD, Salzmann GM, von Knoch F, Tuebel J, Diehl P, Gradinger R, et al. The effects of clindamycin on human osteoblasts in vitro. Arch Orthop Trauma Surg. 2008; 128:317–323. PMID: 18196254.
Article
5. Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res. 1996; 333:245–251. PMID: 8981903.
Article
6. Turan S, Topcu B, Gökçe I, Güran T, Atay Z, Omar A, et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol. 2011; 3:7–11. PMID: 21448327.
Article
7. Tung CB, Tung CF, Yang DY, Hu WH, Hung DZ, Peng YC, et al. Extremely high levels of alkaline phosphatase in adult patients as a manifestation of bacteremia. Hepatogastroenterology. 2005; 52:1347–1350. PMID: 16201071.
8. Quale JM, Mandel LJ, Bergasa NV, Straus EW. Clinical significance and pathogenesis of hyperbilirubinemia associated with Staphylococcus aureus septicemia. Am J Med. 1988; 85:615–618. PMID: 3189364.
Article
9. Peltola H, Pääkkönen M, Kallio P, Kallio MJ. Osteomyelitis-Septic Artghritis (OM-SA) Study Group. Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis. Clin Infect Dis. 2009; 48:1201–1210. PMID: 19323633.
Article
10. Peltola H, Pääkkönen M, Kallio P, Kallio MJ. Osteomyelitis-Septic Arthritis Study Group. Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases. Pediatr Infect Dis J. 2010; 29:1123–1128. PMID: 20842069.
11. Pääkkönen M, Kallio MJ, Kallio PE, Peltola H. C-reactive protein versus Erythrocyte sedimentation rate, white blood cell count and alkaline phosphatase in diagnosing bacteraemia in bone and joint infections. J Paediatr Child Health. 2013; 49:E189–E192. PMID: 23438321.
Article
12. Pääkkönen M, Kallio PE, Kallio MJ, Peltola H. Management of osteoarticular infections caused by Staphylococcus aureus is similar to that of other etiologies: analysis of 199 staphylococcal bone and joint infections. Pediatr Infect Dis J. 2012; 31:436–438. PMID: 22189524.
13. Harel L, Prais D, Bar-On E, Livni G, Hoffer V, Uziel Y, et al. Dexamethasone therapy for septic arthritis in children: results of a randomized double-blind placebo-controlled study. J Pediatr Orthop. 2011; 31:211–215. PMID: 21307717.
14. England K, Thorne C, Pembrey L, Tovo PA, Newell ML. Age- and sex-related reference ranges of alanine aminotransferase levels in children: European paediatric HCV network. J Pediatr Gastroenterol Nutr. 2009; 49:71–77. PMID: 19465871.
Article
15. Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med. 1998; 17:857–872. PMID: 9595616.
Article
16. Tetzlaff TR, Howard JB, McCraken GH, Caldereon E, Larrondo J. Antibiotic concentrations in pus and bone of children with osteomyelitis. J Pediatr. 1978; 92:135–140. PMID: 619056.
Article
17. Nelson JD, Howard JB, Shelton S. Oral antibiotic therapy for skeletal infections of children. I. Antibiotic concentrations in suppurative synovial fluid. J Pediatr. 1978; 92:131–134. PMID: 619055.
18. Yang L, Grey V. Pediatric reference intervals for bone markers. Clin Biochem. 2006; 39:561–568. PMID: 16423337.
Article
19. Huang Y, Eapen E, Steele S, Grey V. Establishment of reference intervals for bone markers in children and adolescents. Clin Biochem. 2011; 44:771–778. PMID: 21531216.
Article
20. Van Hoof VO, De Broe ME. Interpretation and clinical significance of alkaline phosphatase isoenzyme patterns. Crit Rev Clin Lab Sci. 1994; 31:197–293. PMID: 7818774.
Article
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