Ann Lab Med.  2013 Jan;33(1):65-68. 10.3343/alm.2013.33.1.65.

Two Cases of Mycoplasma pneumoniae Pneumonia with A2063G Mutation in the 23S rRNA Gene in Siblings

• Hong JH
• Chun JK
• Uh Y
• Oh KJ
• Kim J
• Yoon KJ

• KMID: 1781300
• DOI: http://doi.org/10.3343/alm.2013.33.1.65

Abstract

We describe 2 cases of pneumonia caused by the same macrolide-resistant Mycoplasma pneumoniae in siblings. M. pneumoniae was identified using real-time PCR. Direct sequence analysis of the 23S rRNA gene revealed a point mutation in V domain (A2063G) of the 23S rRNA gene.

Keyword

Pneumonia; Macrolide; Mycoplasma pneumoniae; 23S rRNA

MeSH Terms

Anti-Bacterial Agents/pharmacology
Child
Child, Preschool
Drug Resistance, Bacterial/drug effects
Humans
Macrolides/pharmacology
Male
Mutation
Mycoplasma pneumoniae/*genetics/isolation & purification
Pneumonia, Mycoplasma/*diagnosis/microbiology/radiography
RNA, Ribosomal, 23S/*analysis
Real-Time Polymerase Chain Reaction
Sequence Analysis, RNA
Siblings
Anti-Bacterial Agents
Macrolides
RNA, Ribosomal, 23S

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