Yonsei Med J.  2006 Aug;47(4):475-479. 10.3349/ymj.2006.47.4.475.

Epstein-Barr Virus Antibodies in Kawasaki Disease

• Lee SJ
• Lee KY
• Han JW
• Lee JS
• Whang KT

• KMID: 1779495
• DOI: http://doi.org/10.3349/ymj.2006.47.4.475

Abstract

The prevalent ages at onset for Kawasaki Disease (KD) and Epstein-Barr virus (EBV) infection are known to be similar in Korea and Japan. We evaluated the correlation between EBV infection and KD. The antibodies to EBV such as anti-viral capsid antigen (VCA) IgG and IgM, anti-diffuse and restricted early antigen IgG (anti-EADR IgG), and the anti-EBV determined nuclear antigen IgG (anti-EBNA IgG) were examined in 29KD patients at five separate times sequentially during a period of one year, and also in 14 other children with a past history of KD. The results of each group were compared with those of age-matched controls. The positive rates of anti-VCA IgG and IgM at presentation in the KD patients were 41.4% (12/29) and 0% (0/29), respectively. Only one patient was found to be anti-VCA IgM-positive within two months. There were no cases of anti-VCA IgG except one, anti-EADR IgG and anti-EBNA IgG positive to negative seroconversion during the year. The children with a past history of KD showed higher anti-EBNA IgG-positive rates than the controls (p=0.04). There was no difference in the seropositive rates of the antibodies to EBV, cytomegalovirus, herpes simplex virus and herpes zoster virus. In conclusion, children with KD were noted to have normal immune responses to EBV infection. Children with a past history of KD seemed to be infected with EBV at a later age than children with no history of KD.

Keyword

Epstein-Barr virus; herpes virus; Kawasaki disease

MeSH Terms

Mucocutaneous Lymph Node Syndrome/*virology
Male
Korea
Infant
Immunoglobulins/metabolism
Immunoglobulin M/chemistry
Immunoglobulin G/chemistry
Humans
Herpesvirus 4, Human/*metabolism
Female
Epstein-Barr Virus Infections/*complications
Child, Preschool
Antibodies, Viral/*chemistry
Age of Onset

Reference

1. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi. 1967. 16:178–222. (Japanese).

2. Sundel RP, Newberger JW. Kawasaki disease. Curr Opin Infect Dis. 1992. 5:664–669.

3. Rowley AH, Gonzalez-Crussi F, Schulman ST. Kawasaki syndrome. Rev Infect Dis. 1988. 10:1–15.

4. Park YW, Han JW, Park IS, Kim CH, Yun YS, Cha SH, et al. Epidemiologic picture of Kawasaki disease in Korea, 2000-2002. Pediatr Int. 2005. 47:382–387.

5. Yanagawa H, Yashiro M, Nakamura Y, Kawasaki T, Kato H. Results of 12 nationwide epidemiological incidence surveys of Kawasaki disease in Japan. Arch Pediatr Adolesc Med. 1995. 149:779–783.

6. Osato T, Kikuda H, Okano M, Mizuno F, Konno M, Ishikawa N, et al. Kawasaki disease and Epstein-Barr virus infection. Prog Clin Biol Res. 1987. 250:113–116.

7. Oh SH, Lee YA, Moon YY, Koh TS, Park YS, Moo HN. Seroprevalence of Epstein-Barr virus in Korean children. J Korean Pediatr Soc. 1994. 37:804–811.

8. Okano M. Epstein-Barr virus infection ant its role in the expanding spectrum of human diseases. Acta Paediatr. 1998. 87:11–18.

9. Iwanaga M, Takada K, Osato T, Saeki Y, Noro S, Sakurada N. Kawasaki disease and Epstein-Barr virus. Lancet. 1981. i:938–939.

10. Kikuta H, Mizuno F, Osato T, Konno M, Ishikawa N, Noro S, et al. Kawasaki disease and an unusual primary infection with Epstein-Barr virus. Pediatrics. 1984. 73:413–414.

11. Okano M, Hase N, Sakiyama Y, Matsumoto S. Long-term observation in patients with Kawasaki syndrome and their relation to Epstein-Barr virus infection. Pediatr Infect Dis J. 1990. 9:139–141.

12. Okano M, Thiele GM, Sakiyama Y, Matsumoto S, Purtilo DT. Adenovirus infection in patients with Kawasaki disease. J Med Virol. 1990. 32:53–57.

13. Kikuta H, Matsumoto S, Osato T. Kawasaki disease and Epstein-Barr virus. Acta Paediatr Jpn. 1991. 33:765–770.

14. Marchette NJ, Melish ME, Hicks R, Kihara S, Sam E, Ching D. Epstein-Barr virus and other herpesvirus infections in Kawasaki syndrome. J Infect Dis. 1990. 161:680–684.

15. Rowley AH, Wolinsky SM, Relman DA, Sambol SP, Sullivan J, Terai M, et al. Search for highly conserved viral and bacterial nucleic acid sequences corresponding to an etiologic agent of Kawasaki disease. Pediatr Res. 1994. 36:567–571.