J Korean Med Sci.  2009 Aug;24(4):695-700. 10.3346/jkms.2009.24.4.695.

Association of Plasma Levels of Resistin with Subcutaneous Fat Mass and Markers of Inflammation but not with Metabolic Determinants or Insulin Resistance

• Won JC
• Park CY
• Lee WY
• Lee ES
• Oh SW
• Park SW

• KMID: 1779206
• DOI: http://doi.org/10.3346/jkms.2009.24.4.695

Abstract

The aim of the present study was to investigate the relationship of plasma resistin levels with determinants of the metabolic syndrome (MetS) and anthropometric parameters in healthy Korean subjects. Plasma resistin levels were determined in 276 subjects. In subjects with MetS, the plasma resistin levels were not significantly increased compared to those without MetS (8.3+/-4.3 ng/mL vs. 8.5+/-3.6 ng/mL, respectively, P=0.84). In addition, the plasma resistin levels were not correlated with the body mass index, the waist circumference, homeostasis model assessment-insulin resistance (HOMA-IR), fasting plasma glucose or insulin levels. However, the plasma resistin levels were positively correlated with the abdominal subcutaneous fat (r=0.18, P<0.01) in all subjects and correlated with TNF alpha(r=-0.16, P<0.05) and hsCRP (r=0.15, P<0.05) in subjects without MetS but not with MetS. With multiple linear regression analysis, these linear associations remained to be significant. The results of this study show that plasma resistin levels in humans were not associated with markers of insulin resistance, obesity or other determinants of the MetS.

Keyword

Resistin; Metabolic Syndrome; C-reactive Protein

MeSH Terms

Adult
Aged
Anthropometry
Biological Markers/blood
Blood Glucose/analysis
Body Mass Index
C-Reactive Protein/metabolism
Female
Humans
Insulin/blood
*Insulin Resistance
Male
Metabolic Syndrome X/diagnosis/*metabolism
Middle Aged
Obesity/diagnosis/metabolism
Resistin/*blood
Subcutaneous Fat/*chemistry
Tumor Necrosis Factor-alpha/metabolism

Figure

• 

  Fig. 1 Mean plasma levels of logarithmic transformed resistin along high-sensitive C-reactive protein (hsCRP) tertile and abdominal subcutaneous fat (SCT) quartile in subjects without the metabolic syndrome. *P<0.05 vs. respective first quartile of hsCRP.

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