J Korean Med Sci.  2005 Jun;20(3):483-488. 10.3346/jkms.2005.20.3.483.

Development of Korean Standard Brain Templates

• Lee JS
• Lee DS
• Kim J
• Kim YK
• Kang E
• Kang H
• Kang KW
• Lee JM
• Kim JJ
• Park HJ
• Kwon JS
• Kim SI
• Yoo TW
• Chang KH
• Lee MC

• KMID: 1778511
• DOI: http://doi.org/10.3346/jkms.2005.20.3.483

Abstract

We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.

Keyword

Brain; Magnetic Resonance Imaging; Positron-Emission Tomography; Atlases; Reference Standards

MeSH Terms

Adolescent
Adult
Age Factors
Aged
Brain/*radiography/*radionuclide imaging
Comparative Study
Female
Fluorodeoxyglucose F18/diagnostic use
Humans
Korea
Magnetic Resonance Imaging/methods
Male
Middle Aged
Positron-Emission Tomography/methods
Research Support, Non-U.S. Gov't
Sex Factors

Figure

• 

  Fig. 1 Flowchart for the strategy used in this study to select optimal target brains. Two different methods were independently used to determine 10 male and 10 female candidates, and those who were commonly selected by both methods were considered as a final candidate. The final target brain for each gender was selected with the consensus of 3 image specialists by considering the age of the subject, asymmetry of brain and size of the ventricles.

• 

  Fig. 2 T1-SPGR MRI templates. (A) Young/midlife man. (B) Elderly man. (C) Young/midlife woman. (D) Elderly woman.

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  Fig. 3 F-18-FDG PET templates. (A) Young/midlife man. (B) Elderly man. (C) Young/midlife woman. (D) Elderly woman.

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