J Korean Med Sci.  2011 Aug;26(8):1007-1013. 10.3346/jkms.2011.26.8.1007.

Association between Genetic Polymorphisms of CYP2D6 and Outcomes in Breast Cancer Patients with Tamoxifen Treatment

• Park HS
• Choi JY
• Lee MJ
• Park S
• Yeo CW
• Lee SS
• Shin JG
• Park BW

• KMID: 1777838
• DOI: http://doi.org/10.3346/jkms.2011.26.8.1007

Abstract

The aim of the study was to evaluate the association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the CYP2D6 genetic polymorphisms in 766 breast cancer patients. Among them, 110 patients whose samples were prospectively collected before surgery and treated with tamoxifen were included to evaluate the association between CYP2D6 and outcomes. The genotypes of CYP2D6 were categorized as extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) according to the activity score. The clinicopathologic features of 110 patients were not significantly different among the three groups except for the T-stage and nodal status. The high T-stage and axillary metastasis were more frequent in the PM group. While recurrence-free and overall survival in the PM group was poorer than the other groups, there was no significant difference between the EM and the IM group. The difference between the PM and the other groups on univariate analysis disappeared on multivariate analysis. These conflicting results suggest that the clinical value of CYP2D6 polymorphisms is still unclear and more large-sized and comprehensively designed trials are necessary.

Keyword

Breast Neoplasms; Cytochrome p-450 CYP2D6; Polymorphism, Single Nucleotide; Survival Analysis; Tamoxifen

MeSH Terms

Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Hormonal/*therapeutic use
Breast Neoplasms/drug therapy/*genetics/mortality
Cytochrome P-450 CYP2D6/*genetics
Female
Genotype
Humans
Kaplan-Meier Estimate
Middle Aged
Neoplasm Staging
*Polymorphism, Single Nucleotide
Tamoxifen/*therapeutic use

Figure

• 

  Fig. 1 Kaplan-Meier Recurrence-free survival and overall survival plots according to metabolizers clustering.

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