- A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
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Lee SY, Ki CS, Hong KS, Kim JW
- KMID: 1733521
- J Korean Med Sci.
- 2004 Oct;19(5):750-752.
- doi: 10.3346/jkms.2004.19.5.750
We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT... -
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- Genetic Polymorphism of CYP2D6 and Clomiphene Concentrations in Infertile Patients with Ovulatory Dysfunction Treated with Clomiphene Citrate
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Ji M, Kim KR, Lee W, Choe W, Chun S, Min WK
- KMID: 2360058
- J Korean Med Sci.
- 2016 Feb;31(2):310-314.
- doi: 10.3346/jkms.2016.31.2.310
CYP2D6 is primarily responsible for the metabolism of clomiphene citrate (CC). The purpose of the present study was to investigate the relationship between CYP2D6 genotypes, concentrations of CC and its... -
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- Association between Genetic Polymorphisms of CYP2D6 and Outcomes in Breast Cancer Patients with Tamoxifen Treatment
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Park HS, Choi JY, Lee MJ, Park S, Yeo CW, Lee SS, Shin JG, Park BW
- KMID: 1777838
- J Korean Med Sci.
- 2011 Aug;26(8):1007-1013.
- doi: 10.3346/jkms.2011.26.8.1007
The aim of the study was to evaluate the association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the CYP2D6 genetic polymorphisms... -
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